Improved Executive Functions and Reduced Craving in Youths with Methamphetamine Addiction: Evidence from Combined Transcranial Direct Current Stimulation with Mindfulness Treatment.
Improved Executive Functions and Reduced Craving in Youths with Methamphetamine Addiction: Evidence from Combined Transcranial Direct Current Stimulation with Mindfulness Treatment.
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DOI：
10.9758/cpn.2021.19.4.653
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发表时间：
2021-11-30
期刊：
影响因子：
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通讯作者：
Taherifard M
中科院分区：
文献类型：
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作者：
Alizadehgoradel J;Imani S;Nejati V;Vanderhasselt MA;Molaei B;Salehinejad MA;Ahmadi S;Taherifard M
经颅直流电刺激（tDCS）和正念练习已被提出作为一种潜在的方法，以改善执行功能（EF）和减少物质使用障碍的人的渴望。基于这些干预措施的神经作用机制，两种非药物干预措施的组合可能具有累加效应。在目前的研究中，tDCS结合正念为基础的物质滥用治疗（MBSAT），以改善EF和减少渴望的效果进行了研究，在早期戒断甲基苯丙胺滥用。将80名（年龄在18至21岁之间的青少年）早期戒断的甲基苯丙胺使用者随机分配到研究组（tDCS组[n = 20]，正念组[n = 20]，正念-tDCS联合组[n = 20]和假手术组[n = 20]）。活动tDCS（1.5 mA，20 min，12次）或假tDCS应用于左背外侧前额叶皮层，MBSAT协议在12个50 min的会议。在测试后阶段（干预后立即）和随访阶段（干预后一个月），与基线值和假刺激组相比，接受真实的tDCS + MBSAT的组合组在大多数EF任务中的表现显著改善。类似地，在所有治疗组中，在干预后观察到渴望的显著减少，但假刺激组没有。有趣的是，与tDCS + MBSAT干预前相比，EF的增加和渴望的减少是相关的。本研究的结果为tDCS + MBSAT组合的临床有效性提供了初步支持，可能影响认知/情感过程。
Transcranial direct current stimulation (tDCS) and mindfulness practices have been proposed as a potential approach to improve executive functions (EFs) and reduce craving in persons with substance use disorders. Based on the neural mechanisms of action of each of these interventions, the combination of both non-pharmacological interventions might have additive effects. In the current study, the effects of tDCS combined with mindfulness-based substance abuse treatment (MBSAT) to improve EFs and reduce craving were investigated in early abstinent methamphetamine abuse. Eighty (youths aged between 18 and 21) early-abstinent methamphetamine users were randomly assigned to the research groups (tDCS group [n = 20], mindfulness group [n = 20], combined mindfulness-tDCS group [n = 20], and sham group [n = 20]). Active tDCS (1.5 mA,20 min, 12 sessions) or sham tDCS was appliedover the left dorsolateral prefrontal cortex and the MBSAT protocol was used over twelve 50-min sessions. Both in the post-test phase (immediately after the intervention) and follow-up phase (one month after the intervention), performance in most EFs tasks significantly improved in the combination group which received real tDCS ＋ MBSAT, as compared to baseline values and sham stimulation group. Similarly, a significant reduction in craving was observed after intervention inall treatment groups, but not the sham stimulation group. Interestingly, the increase in EFs and the reduction in craving post versus pre tDCS ＋ MBSAT intervention were correlated. Findings from the current study provide initial support for the clinical effectiveness of combination tDCS ＋ MBSAT, possibly influencing cognitive/affective processes.