Iron-Catalyzed Acylation of Polyfunctionalized Aryl- and Benzylzinc Halides with Acid Chlorides
Iron-Catalyzed Acylation of Polyfunctionalized Aryl- and Benzylzinc Halides with Acid Chlorides
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DOI：
10.1021/acs.orglett.6b01677
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发表时间：
2016-08-05
期刊：
影响因子：
5.2
通讯作者：
Knochel, Paul
中科院分区：
文献类型：
--
作者：
Benischke, Andreas D.;Leroux, Marcel;Knochel, Paul
FeCl2 （5mol %）在50℃（2-4 h）和25℃（0.5-4 h）催化功能化芳基卤化锌和苯基氯化锌与多种酸氯化物顺利、方便地酰化，得到多功能化二芳基和芳基杂芳基酮。
FeCl2 (5 mol %) catalyzes a smooth and convenient acylation of functionalized arylzinc halides at 50 degrees C (2-4 h) and benzylic zinc chlorides at 25 degrees C (0.5-4 h) with a variety of acid chlorides leading to polyfunctionalized diaryl and aryl heteroaryl ketones.