Effect of protein intake on weight gain and plasma amino acid levels in uremic rats.
Effect of protein intake on weight gain and plasma amino acid levels in uremic rats.
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蛋白质摄入量对尿毒症大鼠体重增加和血浆氨基酸水平的影响。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
M. Swendseid
中科院分区：
文献类型：
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作者：
M. Wang;I. Vyhmeister;J. Kopple;M. Swendseid
体重约为180-200克的慢性尿毒症大鼠和体重相近的假手术对照组分别饲喂含有5%、15%或23%蛋白质的饲料，为期10-12周。在每个蛋白质摄入量水平上，尿毒症动物的体重增加较少，蛋白质效率比对照组低。此外，尿毒症动物血浆中某些氨基酸水平发生改变。其中酪氨酸和酪氨酸/苯丙氨酸比值降低，瓜氨酸、甘氨酸和甲基组氨酸升高。在尿毒症大鼠和对照大鼠中，某些氨基酸（主要是非必需氨基酸）的血浆浓度与蛋白质摄入量呈负相关；在5%蛋白质饲粮中，必需氨基酸与非必需氨基酸的比例显著降低。这些观察结果表明，尿毒症和蛋白质摄入减少都可能影响慢性肾衰竭大鼠的生长和氨基酸代谢。尿毒症大鼠对蛋白质的利用效率较低，这一发现可能表明，蛋白质摄入量的显著减少可能对尿毒症患者的营养状况尤其有害。
Chronically uremic rats weighing approximately 180-200 g and sham-operated controls of similar weight were pair fed diets containing 5, 15 or 23% protein for 10-12 wk. At each level of protein intake, uremic animals gained less weight and had lower protein efficiency ratios than controls. In addition, certain plasma amino acid levels were altered in the uremic animals. These included tyrosine and the tyrosine/phenylalanine ratio, which were decreased, and citrulline, glycine, and the methylhistidines, which were increased. In both uremic and control rats, plasma concentrations of certain amino acids, primarily nonessential ones, varied inversely with protein intake; with the 5% protein diet, the ratio of essential to nonessential amino acids was significantly reduced. These observations indicate that both uremia and reduced protein intake may affect growth and amino acid metabolism in rats with chronic renal failure. The finding that uremic rats utilize protein less efficiently may indicate that marked reductions in protein intake may be particularly hazardous to the nutritional status of the uremic patient.