Bethesda proposals for classification of lymphoid neoplasms in mice
Bethesda proposals for classification of lymphoid neoplasms in mice
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DOI：
10.1182/blood.v100.1.246
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发表时间：
2002-07-01
期刊：
影响因子：
20.3
通讯作者：
Ward, JM
中科院分区：
文献类型：
--
作者：
Morse, HC;Anver, MR;Ward, JM
根据其组织病理学和遗传学特征对小鼠淋巴肿瘤进行分类的共识系统对于参与理解自发性癌症的发病机制或在小鼠中建模人类造血系统疾病的研究人员来说一直是一个难以捉摸的目标。具有小鼠和人类血液病理学专业知识的国际科学家小组与人类癌症小鼠模型联盟的血液病理学小组委员会一起制定了这些疾病的定义和分类标准以及标准化命名法。有助于该方案的基本要素是临床特征，形态学，免疫表型和遗传特征。由此产生的分类与世界卫生组织对人类淋巴肿瘤的分类有许多相似之处，同时认识到可能是物种特异性的差异。这种分类应有助于人类淋巴疾病小鼠模型的交流。
A consensus system for classification of mouse lymphoid neoplasms according to their histopathologic and genetic features has been an elusive target for investigators involved in understanding the pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to develop criteria for definition and classification of these diseases together with a standardized nomenclature. The fundamental elements contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting classification has numerous parallels to the World Health Organization classification of human lymphoid tumors while recognizing differences that may be species specific. The classification should facilitate communications about mouse models of human lymphoid diseases.