Biocompatible cellulose-based superabsorbent hydrogels with antimicrobial activity
Biocompatible cellulose-based superabsorbent hydrogels with antimicrobial activity
复制标题
具有抗菌活性的生物相容性纤维素基超吸收性水凝胶
DOI：
10.1016/j.carbpol.2015.10.057
复制
发表时间：
2016-02-10
影响因子：
11.2
通讯作者：
Chang, Chunyu
中科院分区：
文献类型：
--
作者：
Peng, Na;Wang, Yanfeng;Chang, Chunyu
目前商用的一次性尿布用高吸水性水凝胶存在机械强度低、生物相容性差、抗菌活性差等缺点，容易引起人体皮肤过敏。为了克服这些困难，我们通过季节化纤维素(QC)和天然纤维素在NaOH/尿素水溶液中的简单化学交联，开发了新型的基于纤维素的水凝胶。制备的水凝胶具有高吸水性、高机械强度、良好的生物相容性和良好的抗菌效果。QC的存在不仅通过季铵盐基的静电排斥提高了水凝胶的溶胀率，而且通过将阴离子微生物膜片段吸引到聚阳离子水凝胶的内孔中而使其具有抗菌活性，从而破坏了微生物膜。此外，水凝胶的溶胀性能、机械强度和抗菌活性强烈依赖于水凝胶网络中季铵盐基的含量。获得的数据鼓励将这些水凝胶用于一次性尿布等卫生应用。(C)2015爱思唯尔有限公司。保留所有权利。
Current superabsorbent hydrogels commercially applied in the disposable diapers have disadvantages such as weak mechanical strength, poor biocompatibility, and lack of antimicrobial activity, which may induce skin allergy of body. To overcome these hassles, we have developed novel cellulose based hydrogels via simple chemical cross-linking of quaternized cellulose (QC) and native cellulose in NaOH/urea aqueous solution. The prepared hydrogel showed superabsorbent property, high mechanical strength, good biocompatibility, and excellent antimicrobial efficacy against Saccharomyces cerevisiae. The presence of QC in the hydrogel networks not only improved their swelling ratio via electrostatic repulsion of quaternary ammonium groups, but also endowed their antimicrobial activity by attraction of sections of anionic microbial membrane into internal pores of poly cationic hydrogel leading to the disruption of microbial membrane. Moreover, the swelling properties, mechanical strength, and antibacterial activity of hydrogels strongly depended on the contents of quaternary ammonium groups in hydrogel networks. The obtained data encouraged the use of these hydrogels for hygienic application such as disposable diapers. (C) 2015 Elsevier Ltd. All rights reserved.