Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease.
Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease.
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环境烟草烟雾和黄体酮会改变过敏性气道疾病小鼠模型的肺部炎症和粘膜化生。
DOI：
10.1007/s12016-011-8280-0
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发表时间：
2012
影响因子：
9.1
通讯作者：
Gershwin,LaurelJ
中科院分区：
文献类型：
--
作者：
Mitchell,ValerieL;VanWinkle,LauraS;Gershwin,LaurelJ
The prevalence and severity of asthma is sexually dimorphic. Adult women have a higher incidence of asthma than men. This suggests that this disease may have a hormonal component. Progesterone has been shown to elicit an immune response similar to that seen in allergic asthma and previous studies have shown that progesterone increases total IgE levels in the peripheral blood. In the current study, we examine the effect of environmental tobacco smoke (ETS) and progesterone on hallmarks of asthma pathology in lung tissue with the goal of defining whether progesterone can also exacerbate two key features of airway remodeling: accumulation of eosinophils and increased mucous. We used a mouse model of allergic asthma that includes house dust mite allergen (HDMA). Adult female BALB/c mice were ovariectomized and implanted with time-release progesterone pellets. Mice were housed in filtered air or ETS for 6 weeks (1 mg/m3total suspended particulate) and exposed to HDMA by inhalation. Progesterone alone did not increase mucous cell mass or the abundance of eosinophils but ETS coupled with progesterone exposure resulted in a significant increase in mucous cell metaplasia and increased accumulation of eosinophils in the asthma model. Levels of cytokines in the bronchoalveolar lavage fluid, measured using a multiplex cytokine assay, revealed elevated levels of both interleukin (IL)-5 and IL-12(p40) in HDMA-exposed animals. The addition of progesterone further exacerbated this response. We conclude that progesterone, in the absence of estrogen, exacerbates airway inflammation and airway remodeling induced by the toxicant ETS.
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影响因子：
3.5
作者：
N. Amlaiky;B. Kilpatrick;M. Caron
通讯作者：
M. Caron
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DOI：
--
发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
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作者：
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DOI：
10.1073/pnas.83.24.9358
发表时间：
1986
影响因子：
11.1
作者：
Lanier,SM;Graham,RM;Hess,HJ;Grodski,A;Repaske,MG;Nunnari,JM;Limbird,LE;Homcy,CJ
通讯作者：
Homcy,CJ
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DOI：
10.1161/01.hyp.6.2_pt_2.i7
发表时间：
1984
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Seidman,CE;Hess,HJ;Homcy,CJ;Graham,RM
通讯作者：
Graham,RM
α2-肾上腺素能受体高亲和力放射性碘探针的合成和表征。
影响因子：
3.6
作者：
Lanier,SM;Hess,HJ;Grodski,A;Graham,RM;Homcy,CJ
通讯作者：
Homcy,CJ