Simplified laser-speckle-imaging analysis method and its application to retinal blood flow imaging
Simplified laser-speckle-imaging analysis method and its application to retinal blood flow imaging
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DOI：
10.1364/ol.32.002188
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发表时间：
2007-08-01
期刊：
影响因子：
3.6
通讯作者：
Duong, Timothy Q.
中科院分区：
文献类型：
--
作者：
Cheng, Haiying;Duong, Timothy Q.
激光散斑成像（LSI）被广泛用于高时空分辨率的血流研究。最近有几篇论文指出，常用的LSI方程涉及可能导致不正确数据分析的近似值。我们研究了这种近似的影响，并介绍了一种简化的分析方法，以提高计算时间。进行了流动体模研究以进行确认。此外，我们证明了一种新的LSI的应用成像正常和生理挑战条件下的大鼠视网膜血流。由于血流异常与许多视网膜疾病有关，LSI可以提供有价值的生理和潜在的诊断信息。(C)2007年，美国光学学会。
Laser speckle imaging (LSI) is widely used to study blood flow at high spatiotemporal resolution. Several papers recently pointed out that the commonly used LSI equation involves an approximation that could result in incorrect data analysis. We investigated the impact of such an approximation and introduced a simplified analysis method to improve computation time. Flow phantom studies were performed for validation. Moreover, we demonstrated a novel LSI application by imaging blood flow of rat retinas under normal and physiologic-challenge conditions. Because blood-flow abnormality is implicated in many retinal diseases, LSI could provide valuable physiologic, and potentially diagnostic, information. (C) 2007 Optical Society of America.