Glucocorticoid receptor involvement in pair bonding in female prairie voles: The effects of acute blockade and interactions with central dopamine reward systems
Glucocorticoid receptor involvement in pair bonding in female prairie voles: The effects of acute blockade and interactions with central dopamine reward systems
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DOI：
10.1016/j.neuroscience.2005.04.012
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Wang, Z
中科院分区：
文献类型：
--
作者：
Curtis, JT;Wang, Z
诱导伴侣偏好在一夫一妻制草原田鼠（Microtus ochrogaster）中被用来检验糖皮质激素受体的阻断可能对该物种的雌性有益的可能性。我们首先研究了矿皮质激素受体拮抗剂（螺内酯）或糖皮质激素受体拮抗剂（RU-486）诱导雌性伴侣偏好的能力。尽管RU-486的有效剂量比螺内酯低一个数量级，但这两种拮抗剂的外周给药都能诱导伴侣偏好。然后，我们通过在外周给药RU-486之前使用icv多巴胺受体拮抗剂（氟哌啶醇、SCH23390或eticlopride）治疗雌性，研究了糖皮质激素受体与中枢多巴胺在配对结合中的潜在相互作用。所有多巴胺拮抗剂都能逆转糖皮质激素受体阻断对成对结合的影响。这些结果建立了糖皮质激素急性阻断诱导雌性田鼠配对的能力。此外，这种效应似乎是通过与中枢多巴胺系统的相互作用介导的。总之，这些发现支持了这样一种可能性，即与其他模型系统不同，糖皮质激素受体活性的降低可能会提高雌性草原田鼠的奖励。(c) 2005年由Elsevier Ltd代表IBRO出版。
Induction of partner preferences in monogamous prairie voles (Microtus ochrogaster) was used to examine the possibility that blockade of glucocorticoid receptors may be rewarding in females of this species. We first examined the ability of either a mineralocorticoid receptor antagonist (spironolactone) or a glucocorticoid receptor antagonist (RU-486) to induce partner preferences in females. Peripheral administration of either of the antagonists was capable of inducing partner preferences, although the effective dose for RU-486 was an order of magnitude lower than that for spironolactone. We then examined a potential interaction of glucocorticoid receptor with central dopamine in pair bonding by treating females with i.c.v. dopamine receptor antagonists (haloperidol, SCH23390, or eticlopride) prior to peripheral administration of RU-486. All of the dopamine antagonists were capable of reversing the effects of glucocorticoid receptor blockade on pair bonding. These results establish the ability for acute blockade of glucocorticoid to induce pair bonds in female voles. Further, this effect appears to be mediated via an interaction with central dopamine systems. Together these findings support the possibility that, unlike other model systems, reductions in glucocorticoid receptor activity may enhance reward in female prairie voles. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.