Inflammatory Mediators of Endothelial Injury in Sickle Cell Disease
Inflammatory Mediators of Endothelial Injury in Sickle Cell Disease
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DOI：
10.1016/j.hoc.2013.11.006
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发表时间：
2014-04-01
影响因子：
2.4
通讯作者：
Hoppe, Carolyn C.
中科院分区：
文献类型：
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作者：
Hoppe, Carolyn C.
炎症在镰状细胞病复杂的病理生理中起着关键作用，并驱动导致血管损伤的急性和慢性过程。炎症介质，如细胞粘附分子、细胞因子、白三烯和核因子κ B信号因子，是镰状细胞病的潜在治疗靶点。
Inflammation plays a critical role in the complex pathophysiology of sickle cell disease and drives both the acute and chronic processes leading to vascular injury. Mediators of inflammation, such as cellular adhesion molecules, cytokines, leukotrienes, and nuclear factor kappa B signaling factors, represent potential therapeutic targets in sickle cell disease.