Evolution and Conservation of Bordetella Intracellular Survival in Eukaryotic Host Cells.
Evolution and Conservation of Bordetella Intracellular Survival in Eukaryotic Host Cells.
复制标题
DOI：
10.3389/fmicb.2020.557819
复制
发表时间：
2020
影响因子：
5.2
通讯作者：
Harvill ET
中科院分区：
文献类型：
--
作者：
Rivera I;Linz B;Harvill ET
经典的博德特氏菌具有几个部分特征的毒力机制，在一个完整的细胞外生命周期的背景下，在其哺乳动物宿主的研究。然而，经典的博德特氏菌在临床样品中的树突状细胞（DC）和肺泡巨噬细胞内反复报道，并且体外实验令人信服地证明细菌可以在哺乳动物吞噬细胞内细胞内存活，这种能力似乎是从生活在环境中的祖先物种传下来的，并且获得了抵抗单细胞吞噬性捕食者的机制。已知许多病原体，包括结核分枝杆菌、肠道沙门氏菌、土拉弗朗西斯菌和嗜肺军团菌，在真核宿主细胞内寄生和繁殖。这种策略提供了保护，营养和系统传播的能力。虽然已经有一些工作致力于表征百日咳博德特氏菌的细胞内存活，但对这种策略如何在博德特氏菌属内进化以及这种能力对细菌致病性、逃避宿主免疫以及宿主内和宿主间传播的贡献的理解有限。在这里，我们探讨的机制，控制伴随细胞内生存的代谢变化，以及如何获得和保存在整个进化历史的博德特氏菌属，并讨论这种策略的持久性和重现的B的可能影响。百日咳近年来
The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle in their mammalian hosts. Yet, classical bordetellae have repeatedly been reported within dendritic cells (DCs) and alveolar macrophages in clinical samples, and in vitro experiments convincingly demonstrate that the bacteria can survive intracellularly within mammalian phagocytic cells, an ability that appears to have descended from ancestral progenitor species that lived in the environment and acquired the mechanisms to resist unicellular phagocytic predators. Many pathogens, including Mycobacterium tuberculosis, Salmonella enterica, Francisella tularensis, and Legionella pneumophila, are known to parasitize and multiply inside eukaryotic host cells. This strategy provides protection, nutrients, and the ability to disseminate systemically. While some work has been dedicated at characterizing intracellular survival of Bordetella pertussis, there is limited understanding of how this strategy has evolved within the genus Bordetella and the contributions of this ability to bacterial pathogenicity, evasion of host immunity as well as within and between-host dissemination. Here, we explore the mechanisms that control the metabolic changes accompanying intracellular survival and how these have been acquired and conserved throughout the evolutionary history of the Bordetella genus and discuss the possible implications of this strategy in the persistence and reemergence of B. pertussis in recent years.
登录
查看更多内容
土拉弗氏菌在蓖麻棘球蚴中的存活和生长
影响因子：
4.4
作者：
Abd, H;Johansson, T;Forsman, M
通讯作者：
Forsman, M
影响因子：
3.2
作者：
Christiansen, JK;Larsen, MH;Kallipolitis, BH
通讯作者：
Kallipolitis, BH
影响因子：
3.7
作者：
Ahmed, Niyaz;Saini, Vikram;Hasnain, Seyed E.
通讯作者：
Hasnain, Seyed E.
影响因子：
6.7
作者：
Charity JC;Blalock LT;Costante-Hamm MM;Kasper DL;Dove SL
通讯作者：
Dove SL
bvgas 介导的信号转导--在兔模型中分析锁相调节突变体的博德特氏菌--布鲁氏菌
影响因子：
3.1
作者：
COTTER, PA;MILLER, JF
通讯作者：
MILLER, JF