Gadolinium chelates in angiography and interventional radiology: A useful alternative to iodinated contrast media for angiography
Gadolinium chelates in angiography and interventional radiology: A useful alternative to iodinated contrast media for angiography
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DOI：
10.1148/radiol.2232010742
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发表时间：
2002-05-01
期刊：
影响因子：
19.7
通讯作者：
Hartwell, GD
中科院分区：
文献类型：
--
作者：
Spinosa, DJ;Kaufmann, JA;Hartwell, GD
Gd具有非常适合于射线成像的物理性质。数字减影血管造影术可为诊断和介入治疗提供合适质量的图像。基于Gd的造影剂的整体安全性非常好。特别是，这些造影剂在肾功能不全患者中耐受性良好，动脉内给药剂量低于每公斤体重0.3-0.4 mmol，与类似体积的碘化造影剂相比，造影剂引起的肾病的发生率降低。目前可用的格拉络合物配方可以安全地注射到每一个动脉和静脉结构中。然而，缺乏肾功能不全患者动脉内使用Gd的大量数据，特别是超过磁共振血管成像常规使用的剂量。在接受血管造影术研究的特定高危患者中，适量的格拉络合物是有用的替代造影剂。((C))RSNA，2002。
Gadolinium has physical properties that are well suited for radiographic imaging. Digital subtraction angiography with a gadolinium chelate as contrast medium can provide images of suitable quality for diagnosis and intervention. The overall safety profile of gadolinium-based contrast media is excellent. In particular, these contrast media are well tolerated in patients with renal insufficiency when administered intraarterially in doses of less than 0.3-0.4 mmol per kilogram body weight, with a decreased incidence of contrast medium-induced nephropathy, as compared with similar volumes of iodinated contrast material. The currently available formulations of gadolinium chelates can be injected safely into every arterial and venous structure. However, substantial data are lacking on the intraarterial use of gadolinium in patients with renal insufficiency, particularly at doses that exceed those routinely used in magnetic resonance angiography. Gadolinium chelates in appropriate volumes are useful alternative contrast media in selected high-risk patients undergoing angiographic studies.((C)) RSNA, 2002.