Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases
Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases
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DOI：
10.1186/1471-2407-9-91
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发表时间：
2009-03-24
期刊：
影响因子：
3.8
通讯作者：
Rojas-Martinez, Augusto
中科院分区：
文献类型：
--
作者：
Gomez-Guerra, Lauro S.;Martinez-Fierro, Margarita L.;Rojas-Martinez, Augusto
背景：前列腺癌（PCa）是全世界男性中第二常见的肿瘤。先前的报告表明，西班牙裔男性中 PCa 的患病率低于非洲人（包括非洲血统社区）和白种人，但高于亚洲人。尽管有这些背景，但在拉丁美洲社区开展前列腺癌公开人群筛查的报道却很少。本文描述了对墨西哥蒙特雷城市人口进行的连续3次筛查的结果。 方法：经我校医院内部审查委员会（IRB）批准后，通过广播、电视和媒体宣布筛查，对象一般为40岁以上男性受试者。同意参加的受试者在蒙特雷大都市区 UANL 大学健康项目的初级保健诊所接受评估。从每个受试者身上采集血样进行前列腺特异性抗原（PSA）测定；他们接受了直肠指检（DRE），随后接受采访以获得人口统计和泌尿系统数据。根据 PSA (>4.0 ng/ml) 和 DRE 结果，指定受试者进行经直肠活检 (TRB)。 结果：总共筛选了 973 名受试者。根据 PSA 值和 DRE 结果，建议 125 名男性进行前列腺活检，但其中只有 55 人进行了活检。这些活检男性中有 15 名被诊断患有 PCa，其中大部分的 Gleason 评分 >= 7。结论：我们的结果反映出 PCa 的患病率总体较低，但在 PCa 结果呈阳性的患者中，高级别病变 (Gleason >= 7) 的发生率较高。这一观察结果强调了前列腺癌筛查计划在我们墨西哥社区的重要性以及严格后续活动的必要性。
Background: Prostate Cancer (PCa) is the second most frequent neoplasia in men worldwide. Previous reports suggest that the prevalence of PCa in Hispanic males is lower than in Africans (including communities with African ancestry) and Caucasians, but higher than in Asians. Despite these antecedents, there are few reports of open population screenings for PCa in Latin American communities. This article describes the results of three consecutive screenings in the urban population of Monterrey, Mexico.Methods: After receiving approval from our University Hospital's Internal Review Board (IRB), the screening was announced by radio, television, and press, and it was addressed to male subjects over 40 years old in general. Subjects who consented to participate were evaluated at the primary care clinics of the University Health Program at UANL, in the Metropolitan area of Monterrey. Blood samples were taken from each subject for prostate specific antigen (PSA) determination; they underwent a digital rectal examination (DRE), and were subsequently interviewed to obtain demographic and urologic data. Based on the PSA (>4.0 ng/ml) and DRE results, subjects were appointed for transrectal biopsy (TRB).Results: A total of 973 subjects were screened. Prostate biopsy was recommended to 125 men based on PSA values and DRE results, but it was performed in only 55 of them. 15 of these biopsied men were diagnosed with PCa, mostly with Gleason scores >= 7.Conclusion: Our results reflect a low prevalence of PCa in general, but a high occurrence of high grade lesions (Gleason >= 7) among patients that resulted positive for PCa. This observation remarks the importance of the PCa screening programs in our Mexican community and the need for strict follow-up campaigns.