A clinical overview of centrosome amplification in human cancers.
A clinical overview of centrosome amplification in human cancers.
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DOI：
10.7150/ijbs.7.1122
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发表时间：
2011
影响因子：
9.2
通讯作者：
Chan JY
中科院分区：
文献类型：
--
作者：
Chan JY
21世纪之交，人们对中心体及其与人类癌症发展的因果关系产生了浓厚的兴趣——这一假设已经存在了近一个世纪。中心体扩增（CA）经常在越来越多的人类癌症中检测到，无论是实体癌症还是血液学癌症，都是癌细胞的候选“标志”。一些证据支持CA在早期到晚期癌变过程中的渐进式参与，在癌前病变甚至组织病理学正常组织中也有发现。CA通过多极纺锤体的形成和染色体错分离，构成了导致染色体不稳定和非整倍体的主要机制。在临床上，CA可能转化为更大的恶性转化、肿瘤进展、化疗耐药的风险，最终导致患者预后不良。随着CA的机制逐渐被揭示，中心体已经成为癌症治疗的一个新的候选靶点。这篇综述主要总结了迄今为止关于CA在人类肿瘤中的潜在机制的临床研究，并强调了中心体在人类癌症的诊断、预后和治疗中的潜在应用。
The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers.
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