[3H]Cyclohexyladenosine binding in rat brain: A pharmacological analysis using quantitative autoradiography
[3H]Cyclohexyladenosine binding in rat brain: A pharmacological analysis using quantitative autoradiography
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[3H]环己基腺苷在大鼠脑中的结合：使用定量放射自显影的药理学分析
DOI：
10.1016/0304-3940(86)90226-0
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发表时间：
1986
影响因子：
2.5
通讯作者：
M. Williams
中科院分区：
文献类型：
--
作者：
E. W. Snowhill;M. Williams
采用定量放射自显影技术表征[3H]环己基腺苷（CHA）的区域结合参数，并观察到一系列腺苷激动剂和拮抗剂对[3H]CHA特异性结合的区域抑制作用。在上述[3H]条件下，CHA结合在所有检测区域都被一个单一的、高亲和力的位点模型最适合。在腺苷和黄嘌呤类似物对[3H]CHA结合的抑制作用方面，没有观察到主要的区域差异。总体而言，所有区域的活动等级顺序为CPA>R-PIA>NECA⪢PACPX或2-CADO或S-PIA⪢DPX。
Quantitative autoradiography was used to characterize the regional binding parameters of [3H]cyclohexyladenosine (CHA) and the regional inhibition of specific [3H]CHA binding observed with a series of adenosine agonists and antagonists. Under the conditions described [3H]CHA binding was best fit by a single, high affinity site model in all areas examined. No major regional differences were observed in the inhibition of [3H]CHA binding by the adenosine and xanthine analogs examined. Overall, the rank order of activity throughout all regions was CPA>R-PIA>NECA⪢PACPX⩾2-CADO⩾S-PIA⪢DPX.
脑组织中腺苷 A1 受体结合的异质性。
影响因子：
3.6
作者：
Murphy,KM;Snyder,SH
通讯作者：
Snyder,SH
影响因子：
13.9
作者：
S. Snyder
通讯作者：
S. Snyder