The outpost against cancer: universal cancer only markers.
The outpost against cancer: universal cancer only markers.
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DOI：
10.20892/j.issn.2095-3941.2023.0313
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发表时间：
2023-11-28
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
癌症是全世界死亡的主要原因。早期发现癌症可以降低所有类型癌症的死亡率；然而，大多数类型的癌症都缺乏有效的早期检测生物标志物。 DNA 甲基化一直是人们感兴趣的主要目标，因为 DNA 甲基化通常发生在其他可检测到的遗传变化之前。在使用新型 DNA 甲基化引导定位测序研究癌症的共同特征时，一系列通用癌症专用标记物 (UCOM) 已成为有效、准确地早期检测癌症的有力候选者。虽然当前癌症生物标志物的临床价值因低敏感性和/或低特异性而降低，但 UCOM 的独特特征确保了具有临床意义的结果。 UCOM 在肺癌、宫颈癌、子宫内膜癌和尿路上皮癌中的临床潜力的验证进一步支持了 UCOM 在多种癌症类型和各种临床场景中的应用。事实上，目前UCOM在癌症早期发现、辅助诊断、治疗效果、复发监测等方面的应用正在积极研究和进一步评估。 UCOM 检测癌症的分子机制是下一个需要研究的重要课题。 UCOM在现实场景中的应用也需要实施和完善。
Cancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually occurs before other detectable genetic changes. While investigating the common features of cancer using a novel guide positioning sequencing for DNA methylation, a series of universal cancer only markers (UCOMs) have emerged as strong candidates for effective and accurate early detection of cancer. While the clinical value of current cancer biomarkers is diminished by low sensitivity and/or low specificity, the unique characteristics of UCOMs ensure clinically meaningful results. Validation of the clinical potential of UCOMs in lung, cervical, endometrial, and urothelial cancers further supports the application of UCOMs in multiple cancer types and various clinical scenarios. In fact, the applications of UCOMs are currently under active investigation with further evaluation in the early detection of cancer, auxiliary diagnosis, treatment efficacy, and recurrence monitoring. The molecular mechanisms by which UCOMs detect cancers are the next important topics to be investigated. The application of UCOMs in real-world scenarios also requires implementation and refinement.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
51.1
作者：
Jacobs, Ian;Gentry-Maharaj, Aleksandra;Menon, Usha
通讯作者：
Menon, Usha
DOI：
10.1056/nejmoa1201637
发表时间：
2012-08-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
Heijnsdijk EA;Wever EM;Auvinen A;Hugosson J;Ciatto S;Nelen V;Kwiatkowski M;Villers A;Páez A;Moss SM;Zappa M;Tammela TL;Mäkinen T;Carlsson S;Korfage IJ;Essink-Bot ML;Otto SJ;Draisma G;Bangma CH;Roobol MJ;Schröder FH;de Koning HJ
通讯作者：
de Koning HJ
DOI：
10.1073/pnas.95.20.11891
发表时间：
1998-09-29
影响因子：
11.1
作者：
Belinsky, SA;Nikula, KJ;Herman, JG
通讯作者：
Herman, JG
影响因子：
11.5
作者：
Holyoake, Andrew;O'Sullivan, Paul;Guilford, Parry
通讯作者：
Guilford, Parry