Test-retest reliability of the multifocal electroretinogram and Humphrey visual fields in patients with retinitis pigmentosa
Test-retest reliability of the multifocal electroretinogram and Humphrey visual fields in patients with retinitis pigmentosa
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DOI：
10.1007/s10633-005-0567-0
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发表时间：
2004-11-01
影响因子：
1.4
通讯作者：
Holopigian, K
中科院分区：
文献类型：
--
作者：
Seiple, W;Clemens, CJ;Holopigian, K
我们研究了一组视网膜色素变性（RP）患者Humphrey视野阈值和多焦视网膜电图（mfERG）振幅和时间的可靠性。对8例RP患者和7例对照受试者进行了5次检测：基线（访视#0）、3次每周随访访视（访视#1 - #3）和3个月（访视#4）。对于Humphrey阈值，获得重复访视时dB值之间的差异。计算重复访视时mfERG振幅和隐式时间对数值之间的差异。我们使用这些差异分数的标准差作为可靠性的度量，并使用差异分数的平均值作为进展的度量。我们发现，大多数患者的重复数据比对照组的Humphrey和mfERG更多变。我们发现没有单一因素可以预测患者差异评分的SD的大小或方差。我们建议对每位患者的可靠性进行单独评估。最终，结果测量的选择必须以其可靠性及其评估感兴趣的视觉功能的能力为指导。
We examined the reliability of Humphrey visual field thresholds and multifocal electroretinogram (mfERG) amplitudes and timing in a group of patients with Retinitis Pigmentosa (RP). Eight patients with RP and seven control subjects were tested five times: at baseline (visit #0), at three weekly follow-up visits (visits #1 - #3), and at three months (visit #4). For the Humphrey thresholds, differences between dB values on repeat visits were obtained. Differences between log values on repeat visits were calculated for mfERG amplitude and implicit time. We used the standard deviations of these difference scores as a measure of reliability and the means of the difference scores as a measure of progression. We found that the majority of the patients' repeat data were more variable than that of the control subjects for both the Humphrey and mfERG. We found no single factor that predicted the magnitude, or the variance, of the SD of differences scores for the patients. We recommend that each patient's reliability be assessed individually. Ultimately, the choice of an outcome measure must be guided by its reliability, as well as its ability to assess the visual function of interest.