The immune system and inflammation in breast cancer.
The immune system and inflammation in breast cancer.
复制标题
DOI：
10.1016/j.mce.2013.06.003
复制
发表时间：
2014-01-25
影响因子：
4.1
通讯作者：
Shapiro DJ
中科院分区：
文献类型：
--
作者：
Jiang X;Shapiro DJ
在肿瘤发展的不同阶段，免疫系统可以识别和摧毁肿瘤，或促进其生长。靶向免疫系统的治疗已成为乳腺癌的一种有前途的治疗方式，免疫策略正在临床前和临床模型中进行研究。然而，我们对免疫系统细胞和乳腺癌细胞之间复杂相互作用的理解是不完整的。在这篇文章中，我们回顾了最近的研究结果显示，免疫系统如何发挥双重主机保护和肿瘤促进作用，在乳腺癌的发生和发展。然后，我们讨论了雌激素受体α（ERα）依赖性和ERα非依赖性机制，这些机制使乳腺癌免受免疫监视，使乳腺癌细胞逃避免疫细胞诱导的凋亡，并产生免疫抑制的肿瘤微环境。最后，我们讨论了在肿瘤进展和治疗过程中诱导的促肿瘤性炎症，以及炎症如何促进ERα阳性乳腺癌更具侵袭性的表型。
During different stages of tumor development the immune system can either identify and destroy tumors, or promote their growth. Therapies targeting the immune system have emerged as a promising treatment modality for breast cancer, and immunotherapeutic strategies are being examined in preclinical and clinical models. However, our understanding of the complex interplay between cells of the immune system and breast cancer cells is incomplete. In this article, we review recent findings showing how the immune system plays dual host-protective and tumor-promoting roles in breast cancer initiation and progression. We then discuss estrogen receptor α (ERα)-dependent and ERα-independent mechanisms that shield breast cancers from immunosurveillance and enable breast cancer cells to evade immune cell induced apoptosis and produce an immunosuppressive tumor microenvironment. Finally, we discuss protumorigenic inflammation that is induced during tumor progression and therapy, and how inflammation promotes more aggressive phenotypes in ERα positive breast cancers.