Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite
Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite
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DOI：
10.1016/j.actbio.2009.12.055
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发表时间：
2010-07-01
影响因子：
9.7
通讯作者：
Akagawa, Y.
中科院分区：
文献类型：
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作者：
Morita, K.;Doi, K.;Akagawa, Y.
无机聚磷酸盐(Poly(P))可促进成纤维细胞生长因子与其受体结合，促进成骨细胞分化和钙化。本研究评价了聚(P)吸附在多孔羟基磷灰石(IP-CHA)上作为一种新型骨再生材料的可能性。制备的1%、5%、25%和50%的Poly(P)/IP-CHA复合材料分别在15~20min出现Poly(P)的洗脱峰，其中以50%的Poly(P)/IP-CHA的洗脱峰最高。组织学上，植入兔股骨1周后，所有复合材料和IP-CHA对照组的骨肉芽组织均已渗入骨小孔。而在植入2周时，各组均可见新生板层骨形成，但25%和50%Poly(P)/IP-CHA组的骨再生率明显高于25%和50%PolyP/IP-CHA组。这些结果表明，25%和50%的Poly(P)/IP-CHA复合材料可以促进初始骨再生。(C)2010年Acta Materialia Inc.由爱思唯尔有限公司出版。版权所有。
Inorganic polyphosphate (poly(P)) can promote binding between fibroblast growth factors and their receptors and enhance osteoblastic cell differentiation and calcification. This study evaluated the possibilities for poly(P) adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) as a new bone regeneration material. Prepared 1%, 5%, 25% and 50% poly(P)/IP-CHA composites showed the elution peak of poly(P) between 15 and 20 min, respectively, with the highest value from 50% poly(P)/IP-CHA in vitro. Histologically, at 1 week of placement into the femur of rabbits, granulation tissue had penetrated into the pores in all composites and IP-CHA as a control. In contrast, at 2 weeks of placement, newly formed lamellar bone was found in all groups, although a higher amount of bone regeneration was obviously formed in the 25% and 50% poly( P)/IP-CHA with a significantly higher value of bone regeneration ratio of 50% poly(P)/IP-CHA. These results indicate that 25% and 50% poly(P)/IP-CHA composites may enhance initial bone regeneration. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.