Gastrointestinal Stromal Tumor: New Insights for a Multimodal Approach.
Gastrointestinal Stromal Tumor: New Insights for a Multimodal Approach.
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DOI：
10.1016/j.soc.2022.03.007
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发表时间：
2022-07
影响因子：
1.9
通讯作者：
Sicklick, Jason K.
中科院分区：
文献类型：
--
作者：
Sharma, Ashwyn K.;Kim, Teresa S.;Bauer, Sebastian;Sicklick, Jason K.
关键词：
胃肠道间质瘤（GIST）虽然罕见，但在世界范围内每年的发病率约为百万分之7至19例，是胃肠道最常见的肉瘤。1,2这些肿瘤被推测起源于Cajal的间质细胞（ICCs），或胃肠道的起搏器细胞。虽然这些肿瘤可以发生在整个肠道的任何地方，但它们最常见于胃（55%）和小肠（30%）。这些肿瘤中有少数发生在结肠、直肠和食道，甚至在胃肠道外（即肠外）。临床表现通常无特异性，症状包括腹痛、恶心、呕吐、腹围增大、食欲不振、早饱、急性出血或慢性贫血。GIST的特点是KIT或PDGFRA基因的致癌功能获得突变，以及其他驱动因素，包括SDHx亚基、NF1、BRAF、FGFR1和ETV6-NTRK3融合的改变。由于在20世纪90年代后期发现了KIT的基因组改变，GIST已成为精确肿瘤学的范例
Gastrointestinal stromal tumor (GIST), although rare, with an incidence of approximately 7 to 19 cases per million annually around the world, is the most common sarcoma of the gastrointestinal (GI) tract. 1, 2 These tumors are hypothesized to arise from the interstitial cells of Cajal (ICCs), or the pacemaker cells of the GI tract. Although these tumors can occur anywhere throughout the gut, they are most often found in the stomach (55%) and small intestine (30%). A minority of these tumors are found in the colon, rectum, and esophagus, as well as even outside the GI tract (ie, extraintestinal). The clinical presentation is often nonspecific, and symptoms can include abdominal pain, nausea, vomiting, increasing abdominal girth, loss of appetite, early satiety, acute bleeding, or chronic anemia.GIST is characteristically known for oncogenic gain-of-function mutations in the KIT or PDGFRA genes, as well as other drivers, including alterations in SDHx subunits, NF1, BRAF, FGFR1, and ETV6-NTRK3 fusions. As a result of the identification of genomic alterations in KIT in the late 1990s, GIST has become the paradigm for precision oncology
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影响因子：
3.7
作者：
Agaram, Narasimhan P.;Wong, Grace C.;Guo, Tianhua;Maki, Robert G.;Singer, Samuel;DeMatteo, Ronald P.;Besmer, Peter;Antonescu, Cristina R.
通讯作者：
Antonescu, Cristina R.
DOI：
10.1097/coc.0000000000000659
发表时间：
2020-04-01
影响因子：
2.6
作者：
Florindez, Jorge;Trent, Jonathan
通讯作者：
Trent, Jonathan
影响因子：
8.4
作者：
Du, Chun-Yan;Zhou, Ye;Shi, Ying-Qiang
通讯作者：
Shi, Ying-Qiang
DOI：
10.1016/s1470-2045(20)30168-6
发表时间：
2020-07
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Blay JY;Serrano C;Heinrich MC;Zalcberg J;Bauer S;Gelderblom H;Schöffski P;Jones RL;Attia S;D'Amato G;Chi P;Reichardt P;Meade J;Shi K;Ruiz-Soto R;George S;von Mehren M
通讯作者：
von Mehren M
DOI：
10.1056/nejmoa1714448
发表时间：
2018-02-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Drilon A;Laetsch TW;Kummar S;DuBois SG;Lassen UN;Demetri GD;Nathenson M;Doebele RC;Farago AF;Pappo AS;Turpin B;Dowlati A;Brose MS;Mascarenhas L;Federman N;Berlin J;El-Deiry WS;Baik C;Deeken J;Boni V;Nagasubramanian R;Taylor M;Rudzinski ER;Meric-Bernstam F;Sohal DPS;Ma PC;Raez LE;Hechtman JF;Benayed R;Ladanyi M;Tuch BB;Ebata K;Cruickshank S;Ku NC;Cox MC;Hawkins DS;Hong DS;Hyman DM
通讯作者：
Hyman DM