Long-Term Impact of Maternal Substance Use During Pregnancy and Extrauterine Environmental Adversity: Stress Hormone Levels of Preadolescent Children
Long-Term Impact of Maternal Substance Use During Pregnancy and Extrauterine Environmental Adversity: Stress Hormone Levels of Preadolescent Children
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DOI：
10.1203/pdr.0b013e3182291b13
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发表时间：
2011-08-01
影响因子：
3.6
通讯作者：
Higgins, Rosemary D.
中科院分区：
文献类型：
--
作者：
Bauer, Charles R.;Lambert, Brittany L.;Higgins, Rosemary D.
产前可卡因暴露（PCE）与子宫外环境中迟钝的应激反应有关。本研究调查了具有高生物学和/或社会风险的青春期前儿童PCE与每日唾液皮质醇水平之间的关系（n = 725）。唾液样本在他们家中采集。分析显示各组在傍晚或早晨的基础皮质醇水平没有差异；然而，PCE程度较高的儿童在控制其他危险因素的情况下，皮质醇在一夜之间的增加减弱。种族和照顾者抑郁也与皮质醇的昼夜模式有关。虽然反复的PCE可能会导致以后生活中正常或预期的应激反应的改变，但社会人口统计学和环境因素在理解激素生理学方面同样重要，特别是随着PCE发生时间的延长，预测正常保护性皮质醇应激反应能力改变的潜在长期医学、发育或行为影响对于优化PCE患儿的预后至关重要。213 - 219年,2011年)
Prenatal cocaine exposure (PCE) is associated with blunted stress responsivity within the extrauterine environment. This study investigated the association between PCE and diurnal salivary cortisol levels in preadolescent children characterized by high biological and/or social risk (n = 725). Saliva samples were collected at their home. Analyses revealed no group differences in basal evening or morning cortisol levels; however, children with higher degrees of PCE exhibited blunted overnight increases in cortisol, controlling for additional risk factors. Race and caregiver depression were also associated with diurnal cortisol patterns. Although repeated PCE may contribute to alterations in the normal or expected stress response later in life, sociodemographic and environmental factors are likewise important in understanding hormone physiology, especially as more time elapses from the PCE. Anticipating the potential long-term medical, developmental, or behavioral effects of an altered ability to mount a normal protective cortisol stress response is essential in optimizing the outcomes of children with PCE. (Pediatr Res 70: 213-219, 2011)