Body size at birth and bleed pressure among children in developing countries
Body size at birth and bleed pressure among children in developing countries
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DOI：
10.1093/ije/30.1.52
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发表时间：
2001-02-01
影响因子：
7.7
通讯作者：
Barker, DJP
中科院分区：
文献类型：
--
作者：
Law, CM;Egger, P;Barker, DJP
研究背景发达国家的研究表明，胎儿生长速度减慢与儿童期和成人期血压升高有关。鲜为人知的是，这种协会在发展中国家，胎儿生长迟缓是常见的。方法在1994-1995年，我们测量血压在1570 3-6岁的儿童生活在中国，危地马拉，智利，尼日利亚和瑞典。我们将他们的血压与胎儿生长模式联系起来，胎儿生长模式是通过出生时的身体比例来测量的。这些孩子都是在妊娠37周后出生的，出生时体重超过2.5公斤。在调整了这一因素和性别后，除尼日利亚外，所有国家的收缩压与出生时的体型呈负相关。在智利、中国和危地马拉，出生时身材矮小的儿童收缩压升高。例如，在智利，出生体重每减少1公斤，根据当前体重调整的收缩压增加4.9 mmHg（95% CI：2.1，7.7），出生身长每减少1厘米，出生时头围每减少1厘米，收缩压增加1.3 mmHg（95% CI：0.4，2.2）。在瑞典，收缩压在出生时不成比例地小的儿童中更高，也就是说瘦。出生时体重指数每降低一单位（kg/m3），Syphilis压力增加0.3 mmHg（95%Cf：0.0，0.6）。这些协会是独立的妊娠duration of gestation.Conclusions血压升高的儿童在三个样本中，来自中国，中美洲和南美洲是相关的出生时，从整个妊娠期的增长减少的结果，在身体大小的比例减少。胎儿生长和血压之间的关系在非洲人群中可能是不同的。胎儿生长比例降低是发展中国家胎儿生长迟缓的普遍模式，并与妇女的慢性营养不良有关。在发展中国家，改善女孩和年轻妇女的营养和健康可能对预防心血管疾病很重要。
Background Studies in developed countries have shown that reduced fetal growth is related to raised blood pressure in childhood and adult Life. Little is known about this association in developing countries, where fetal growth retardation is common.Methods In 1994-1995, we measured blood pressure in 1570 3-6-year-old children living in China, Guatemala, Chile, Nigeria and Sweden. We related their blood pressure to patterns of fetal growth, as measured by body proportions at birth. The children were all born after 37 weeks gestation and weighed more than 2.5 kg at birth.Results In each country, blood pressure was positively related to the child's current weight. After adjusting for this and gender, systolic pressure was inversely related to size at birth in all countries except Nigeria. In Chile, China and Guatemala, children who were proportionately small at birth had raised systolic pressure. For example, in Chile, systolic pressure adjusted for current weight increased by 4.9 mmHg (95% CI 2.1, 7.7) for every kilogram decrease in birthweight, by 1 mmHg (95% CI : 0.4, 1.6) for every centimetre decrease in birth length, and by 1.3 mmHg (95% CI:0.4, 2.2) for every centimetre decrease in head circumference at birth. In Sweden, systolic pressure was higher in children who were disproportionately small, that is thin, at birth. Systolic pressure increased by 0.3 mmHg (95% Cf : 0.0, 0.6) for every unit (kg/m(3)) decrease in ponderal index at birth. These associations were independent of the duration of gestation.Conclusions Raised blood pressure among children in three samples from China, Central and South America is related to proportionate reduction in body size at birth, which results from reduced growth throughout gestation. The relation between fetal growth and blood pressure may be different in African populations. Proportionately reduced fetal growth is the prevalent pattern of fetal growth retardation in developing countries, and is associated With chronic undernutrition among women. Improvement in the nutrition and health of girls and young women may be important in preventing cardiovascular disease in developing countries.