A ten-year review of commercial vaccine performance for control of tick infestations on cattle
A ten-year review of commercial vaccine performance for control of tick infestations on cattle
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DOI：
10.1017/s1466252307001193
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发表时间：
2007-06-01
影响因子：
2.5
通讯作者：
Willadsen, Peter
中科院分区：
文献类型：
--
作者：
de la Fuente, Jose;Almazan, Consuelo;Willadsen, Peter
蜱虫是家畜和野生动物的重要体外寄生虫，蜱虫侵染在经济上影响全球的牛生产。控制牛蜱感染主要是通过施用杀螨剂，这导致了抗性蜱的选择和环境污染。在这里，我们讨论了澳大利亚，古巴，墨西哥和其他拉丁美洲国家的蜱疫苗应用数据。基于微小牛蜱Bm86肠道抗原的商业牛蜱疫苗已被证明是一种可行的蜱控制方法，为使用杀螨剂提供了一种具有成本效益的环境友好型替代方法。商业蜱疫苗减少了蜱对牛的感染和杀螨剂的使用强度，以及增加了动物产量和减少了一些蜱传播病原体的传播。尽管由于抗原发现的限制、在牛中测试疫苗的费用和公司重组，蜱疫苗的商业化一直很困难，但这些疫苗在过去十年中的成功已经清楚地证明了它们作为牛蜱控制的改进方法的潜力。新的和有效的分子技术用于抗原发现和迫切需要蜱控制方法来减少或取代杀螨剂的使用，特别是在广泛的蜱抗药性已经发生的地区，将大大提高未来改进疫苗的开发。
Ticks are important ectoparasites of domestic and wild animals, and tick infestations economically impact cattle production worldwide. Control of cattle tick infestations has been primarily by application of acaricides which has resulted in selection of resistant ticks and environmental pollution. Herein we discuss data from tick vaccine application in Australia, Cuba, Mexico and other Latin American countries. Commercial tick vaccines for cattle based on the Boophilus microplus Bm86 gut antigen have proven to be a feasible tick control method that offers a cost-effective, environmentally friendly alternative to the use of acaricides. Commercial tick vaccines reduced tick infestations on cattle and the intensity of acaricide usage, as well as increasing animal production and reducing transmission of some tick-borne pathogens. Although commercialization of tick vaccines has been difficult owing to previous constraints of antigen discovery, the expense of testing vaccines in cattle, and company restructuring, the success of these vaccines over the past decade has clearly demonstrated their potential as an improved method of tick control for cattle. Development of improved vaccines in the future will be greatly enhanced by new and efficient molecular technologies for antigen discovery and the urgent need for a tick control method to reduce or replace the use of acaricides, especially in regions where extensive tick resistance has occurred.