Dominance of ipsilateral corticospinal pathway in congenital mirror movements
Dominance of ipsilateral corticospinal pathway in congenital mirror movements
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DOI：
10.1136/jnnp.2004.040949
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发表时间：
2005-02-01
影响因子：
11
通讯作者：
Shibasaki, H
中科院分区：
文献类型：
--
作者：
Ueki, Y;Mima, T;Shibasaki, H
目的：探讨先天性镜像运动的发生机制。设计：采用三重刺激技术（TST）和静默期对一例先天性镜像运动患者进行研究。TST用于计算从两个半球到脊髓运动神经元的同侧和对侧皮质脊髓束的比例。结果：经颅磁刺激单侧M1引起的同侧运动诱发电位大于对侧。支配指外展肌的脊髓运动神经元只有9%在对侧初级运动皮层（M1）刺激下兴奋，而94%在同侧M1刺激下兴奋。在镜像运动和模仿镜像运动时自愿收缩右第一背骨间肌时检查沉默期。左侧M1刺激（通过交叉的皮质脊髓束）在两种情况下的沉默期没有任何差异，而右侧M1刺激（通过未交叉的皮质脊髓束）在镜像运动时比在自愿收缩时引起更长的沉默期。结论：结果表明，镜像运动可能是由同侧M1和通过同侧皮质脊髓通路传递的镜像运动之间的紧密联系引起的。
Objective: To clarify the mechanism of congenital mirror movements.Design: The triple stimulation technique (TST) and the silent period were used to investigate a patient with congenital mirror movements. The TST was used to calculate the ratio of ipsilateral to contralateral corticospinal tracts from the two hemispheres to the spinal motor neurones.Results: Transcranial magnetic stimulation over unilateral M1 induced larger ipsilateral than contralateral motor evoked potentials on both sides. Only 9% of spinal motor neurones innervating the abductor digitorum minimi were excited by contralateral primary motor cortex ( M1) stimulation, while 94% were excited by the ipsilateral M1 stimulation. The silent period was examined during mirror movements and with voluntary contraction of the right first dorsal interosseus mimicking mirror movements. Left M1 stimulation ( through the crossed corticospinal tract) did not show any difference in silent period between the two conditions, while right M1 stimulation ( through the uncrossed tract) caused a longer silent period during mirror movements than during voluntary contractions.Conclusions: The results suggest that mirror movements may be caused by a strong connection between ipsilateral M1 and the mirror movements conveyed through a dominant ipsilateral corticospinal pathway.