Naturally Occurring Arbutin Derivatives and Their Bioactivities
Naturally Occurring Arbutin Derivatives and Their Bioactivities
复制标题
天然熊果苷衍生物及其生物活性
DOI：
10.1002/cbdv.201300269
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发表时间：
2015
影响因子：
2.9
通讯作者：
Zhao Ping
中科院分区：
文献类型：
--
作者：
Xu Wei-Hui;Liang Qian;Zhang Ying-Jun;Zhao Ping
1.导言-熊果苷(4-羟基苯基β-d-吡喃葡萄糖苷；1)是一种常见的黑色素生物合成抑制剂，在化妆品行业中已被广泛用作皮肤美白剂[1-3]。它还可以转化为具有抗菌、收敛和消毒特性的对苯二酚[4]。熊果苷(1)首先在熊果(Arctostaurlos UVA-ursi；Ericaceae)的干燥叶中发现[5]。近年来，从100多种不同的植物中分离出了一些天然衍生的熊果苷衍生物(表1)。熊果苷衍生物是一类重要的、结构多样的天然化合物，从酰化熊果苷代谢物、非酰化熊果苷衍生物到同型和异型熊果苷。据报道，这些天然熊果苷衍生物具有广泛的重要生物学特性，如抗氧化剂[6-11]、抗菌[12-11]。
1. Introduction.–Arbutin (¼4-hydroxyphenyl β-d-glucopyranoside; 1), a common inhibitor of melanin biosynthesis, has been widely used as a skin-whitening agent in cosmetics industry [1–3]. It also can be converted into hydroquinone with antimicrobial, astringent, and disinfectant properties [4]. Arbutin (1) was first found in the dried leaves of bearberry (Arctostaphylos uva-ursi; Ericaceae)[5]. In recent years, a number of naturally derived arbutin derivatives have been isolated from more than 100 different plant species (Table 1). Arbutin derivatives constitute one of the important and structurally diverse classes of naturally occurring compounds, ranging from acylated arbutin metabolites, non-acylated arbutin derivatives to homo-and isohomoarbutins. These natural arbutin derivatives have been reported to exhibit a wide range of significant biological properties such as antioxidant [6–11], antimicrobial [12–