Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma
Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma
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DOI：
10.2147/cmar.s187780
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发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Xiao, Mang
中科院分区：
文献类型：
--
作者：
Jiang, Xiaohua;Ye, Jing;Xiao, Mang
头颈鳞状细胞癌 (HNSCC) 因肿瘤部位、组织学类型、分子特征和临床结果而存在很大差异。近年来，新兴的靶向疗法一直集中在驱动基因上。 HNSCC 涉及多种基因改变，例如共现、多重反馈循环和串扰通讯。这些不同类型的基因改变相互作用并介导靶向治疗反应。在当前的综述中，强调未来 HNSCC 的治疗策略将不仅仅基于针对过度激活基因的“合成致死”方法。更重要的是，将考虑 HNSCC 的生物学、遗传和表观遗传改变来指导治疗。详细讨论了 HNSCC 中出现的基因改变及其对靶向治疗反应的影响。希望能够开发出治疗 HNSCC 的新联合方案。
Head and neck squamous cell carcinoma (HNSCC) is highly variable by tumor site, histologic type, molecular characteristics, and clinical outcome. During recent years, emerging targeted therapies have been focused on driver genes. HNSCC involves several genetic alterations, such as co-occurrence, multiple feedback loops, and cross-talk communications. These different kinds of genetic alterations interact with each other and mediate targeted therapy response. In the current review, it is emphasized that future treatment strategy in HNSCC will not solely be based on "synthetic lethality" approaches directed against overactivated genes. More importantly, biologic, genetic, and epigenetic alterations of HNSCC will be taken into consideration to guide the therapy. The emerging genetic alterations in HNSCC and its effect on targeted therapy response are discussed in detail. Hopefully, novel combination regimens for the treatment of HNSCC can be developed.