White matter correlates of clinical function in schizophrenia using diffusion tensor imaging.
White matter correlates of clinical function in schizophrenia using diffusion tensor imaging.
复制标题
使用扩散张量成像白质与精神分裂症的临床功能相关。
DOI：
10.1016/j.schres.2009.09.043
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发表时间：
2010
影响因子：
4.5
通讯作者：
Nahas,Ziad
中科院分区：
文献类型：
--
作者：
Herbsman,Tal;Nahas,Ziad
到目前为止，来自扩散张量成像（DTI）文献的大量证据表明，精神分裂症患者可能存在结构差异，并且可能与这种疾病的一些临床表现有关1。DTI是一种磁共振成像技术，可测量局部水扩散率，反映大脑大白色物质束中轴突膜和髓鞘的几何特性和方向性。精神分裂症患者脑内最常见的DTI异常包括前额叶和颞叶FA降低，以及前扣带回、弓状束和钩束FA降低。很少有研究试图将FA变化与临床测量相关联2 -4。我们报告了一个基于轨道的空间统计（TBSS）5分析白色物质分数各向异性（FA）之间的差异未服药的精神分裂症患者和对照组。作为二次和探索性分析，我们还报告了精神分裂症亚组中WM相关的临床指标（PANSS、SANS和卡尔加里抑郁量表），我们招募了13名未服药的受试者（平均年龄37.4岁）和16名对照者（平均年龄41.1岁，无DSM-IV轴I诊断）。除就业状况外，受试者和对照组在任何人口统计学变量上均无显著差异。精神分裂症受试者在扫描前至少两周未使用药物。受试者的平均PANS评分为91+/− 17，平均SANS评分为47+/− 16，卡尔加里抑郁量表评分为3.6+/− 3.4。每名参与者均使用带有SENSE线圈的3 T临床MRI扫描仪（Intera，Philips Medical Systems;博瑟尔，华盛顿州）进行MRI扫描。DTI采集由单次激发自旋回波、回波平面成像采集组成，并行成像因子为2，部分傅立叶因子为80%，TR= 5秒，TE= 100 ms，层厚= 3 mm，间隙= 0.3 mm，视野为
There is by now a robust body of evidence from the diffusion tensor imaging (DTI) literature that structural differences likely exist in patients with schizophrenias and may be linked to some of the clinical manifestations of this illness1. DTI is a magnetic resonance imaging technique that measures localized water diffusivity reflecting the geometric properties and directionality of both axonal membrane and myelin in large white matter tracts of the brain. The most often found DTI abnormalities in the brain of patients with schizophrenia include lower prefrontal and temporal lobe FA, as well as lower FA in the anterior cingulum, arcuate and uncinate fasciculi. Far fewer studies have attempted to correlate FA changes with clinical measures2–4. We report on a tract-based spatial statistics (TBSS) 5 analysis of white matter fractional anisotropy (FA) differences between unmedicated patients with schizophrenia and controls. As a secondary and exploratory analysis, we also report on WM correlates of clinical measures (PANSS, SANS and Calgary depression scale) in the schizophrenia subgroup.We enrolled thirteen unmedicated subjects (mean age 37.4 years) and sixteen controls (mean age 41.1 years, no DSM-IV axis I diagnosis). Subjects and controls did not differ significantly in any demographic variables except employment status. Subjects with schizophrenia had not used medications for at least two weeks prior to scanning. Subjects’ mean PANS score was 91+/− 17, mean SANS 47+/− 16 and Calgary Depression Scale mean 3.6+/− 3.4. Each participant had MRI scanning performed using a 3T clinical MRI scanner with a SENSE coil (Intera, Philips Medical Systems; Bothell, WA). DTI acquisition consisted of a single-shot spin echo, echo planar imaging acquisition with a parallel imaging factor of 2 and a partial Fourier factor of 80% with TR= 5 seconds, TE= 100 ms, slice thickness= 3 mm, gap= 0.3 mm, field of