Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise
Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise
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DOI：
10.1291/hypres.29.65
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发表时间：
2006-02-01
影响因子：
5.4
通讯作者：
Matsuda, M
中科院分区：
文献类型：
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作者：
Otsuki, T;Maeda, S;Matsuda, M
随着年龄的增长，全身动脉顺应性(SAC)降低会增加左心室后负荷。本研究旨在研究年龄相关的SAC降低是否与次极量有氧运动中过多的心肌耗氧有关。我们研究了老年人(60-69岁；n=25)和老年(70-82岁；n=25)受试者。在坡道运动开始前(20W热身运动结束时)测量SAC，并在坡道运动(20~50W)中测量双倍乘积(DP：收缩压×心率)。老年组SAC(0.76±0.25ml mm Hg(-1)m(-2))显著低于老年组(0.95±0.22ml mm Hg(-1)m(-2))。老年组Dp(20W：14.3+/-3.1；30W：15.9+/-4.2；40W：17.7+/-4.9；50W：20.6+/-5.6[x 10(3)mm Hg bpm])高于老年组(12.8+/-3.0，14.0+/-3.5，15.1+/-4.0，17.1+/-4.3[x 10(3)mm Hg bpm])。在所有受试者中，SAC与DID显著相关(r=-0.64，r=-0.64)。老年人SAC与DP呈显著正相关(r=-0.83，r=-0.78，r=-0.76，r=-0.74)。老年人SAC与DP呈正相关(r=-0.34，r=-0.36，r=-0.33，r=-0.31)。老年受试者在各个运动强度下的相关系数显著高于老年受试者。这些结果表明，与年龄相关的SAC下降与老年人在次极量有氧运动中过度的心肌耗氧有关，但这种关系在SAC下降变得明显之前并不显著。
Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n = 25) and senior (70-82 years; n = 25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (Le., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure x heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects (0.76 +/- 0.25 ml mmHg(-1) m(-2)) compared with elderly subjects (0.95 +/- 0.22 ml mmHg(-1) m(-2)). DP was higher in senior subjects (20 W: 14.3 +/- 3.1; 30 W: 15.9 +/- 4.2; 40 W: 17.7 +/- 4.9; 50 W: 20.6 +/- 5.6 [x 10(3) mmHg bpm]) than in elderly subjects (12.8 +/- 3.0, 14.0 +/- 3.5, 15.1 +/- 4.0, 17.1 +/- 4.3 [x 10(3) mmHg bpm]). In total subjects, SAC correlated significantly with DID (r = -0.64, r = -0.64, r = -0.64, r = -0.64). In senior subjects, SAC was related significantly to DP (r = -0.83, r = -0.78, r = -0.76, r = -0.74). In elderly subjects, SAC tended to correlate with DP although its relationships were not statistically significant (r = -0.34, r = -0.36, r = -0.33, r = -0.31). Correlation coefficients at each respective exercise intensity were significantly higher in senior subjects compared with elderly subjects. These results suggest that the age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise in older humans, but this relation does not become significant until the SAC reduction becomes pronounced.