An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis
An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis
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DOI：
10.1136/ard.62.3.208
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发表时间：
2003-03-01
影响因子：
27.4
通讯作者：
Johansson, G
中科院分区：
文献类型：
--
作者：
Sköldstam, L;Hagfors, L;Johansson, G
目的：调查的疗效地中海饮食（MD）与普通西方饮食抑制疾病活动的患者类风湿关节炎（RA）。方法：患者控制良好，虽然活跃的RA至少两年的时间，谁正在接受稳定的药物治疗，被邀请参加。所有患者被随机分配到MD或对照饮食（CD）。为了达到良好的遵守规定的饮食，所有患者的前三个星期提供的MD或CD，分别为午餐和晚餐在门诊诊所的食堂。在基线时进行临床检查，并在第3、6和12周再次进行临床检查。综合疾病活动指数（DAS 28），身体功能指数（健康。评估问卷（HAQ）），一种生活质量的健康调查（SF-36简表）和非甾体类抗炎药的每日消耗量作为主要疗效变量。从基线到研究结束，MD组患者（n = 26）显示DAS 28降低0.56在SF-36健康调查的两个维度中：“活力”增加了11.3（p = 0.018），“与一年前相比”减少了0.6（p = 0.016）。对于对照患者（n = 25），在研究结束时未观察到显著变化。两个治疗组之间的这种差异是显着的，只有在下半年的trial.Conclusion：结果表明，RA患者，通过调整地中海饮食，没有获得减少炎症活动，增加身体功能，并提高活力。
Objective: To investigate the efficacy of a Mediterranean diet (MD) versus an ordinary Western diet for suppression of disease activity in patients with rheumatoid arthritis (RA).Methods: Patients with well controlled, although active RA of at least two years' duration, who were receiving stable pharmacological treatment, were invited to participate. All patients were randomly allocated to the MD or the control diet (CD). To achieve good compliance with prescribed diets all patients were for the first three weeks served the MD or the CD, respectively, for lunch and dinner at the outpatient clinic's canteen. Clinical examinations were performed at baseline, and again in the 3rd, 6th, and 1 2th week. A composite disease activity index (DAS28), a physical function index (Health. Assessment Questionnaire (HAQ)), a health survey of quality of life (Short Form-36 (SF-36)), and the daily consumption of non-steroidal anti-inflammatory drugs were used as primary efficacy variables.Results: From baseline to the end of the study the patients in the MD group (n = 26) showed a decrease, in DAS28 of 0.56 (p < 0.001), in HAQ of 0.15 (p = 0.020), and in two dimensions of the SF-36 Health Survey: an increase in "vitality" of 11.3 (p = 0.018) and a decrease in "compared with one year earlier" of 0.6 (p = 0.016). For the control patients (n = 25) no significant change was seen at the end of the study. This difference between the two treatment groups was notable only in the second half of the trial.Conclusion: The results indicate that patients with RA, by adjusting to a Mediterranean diet, did obtain a reduction in inflammatory activity, an increase in physical function, and improved vitality.