Memory regulation in feeding habit transformation to dead prey fish of Chinese perch (Siniperca chuatsi)
Memory regulation in feeding habit transformation to dead prey fish of Chinese perch (Siniperca chuatsi)
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中华鲈鱼死亡猎物食性转变的记忆调节
DOI：
10.1007/s10695-021-01001-z
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发表时间：
2021-09
影响因子：
2.9
通讯作者：
Hui Liang
中科院分区：
文献类型：
--
作者：
Linjie Shi;Jiao Li;Xu‑Fang Liang;Shan He;Yaqi Dou;Jian Peng;Wenjing Cai;Hui Liang
记忆驱动了鲈鱼摄食习性转变的一个关键过程，当他们重新训练吃死猎物鱼。为探讨环腺苷酸反应元件结合蛋白（CREB）信号通路对鲈鱼摄食习惯转变记忆的调控机制，测定了对照组（1次训练）和实验组（2次训练）的CREB上游信号蛋白磷酸化水平。结果表明，再训练与鲈鱼细胞外调节蛋白激酶（ERK 1/2）和钙/钙调素依赖性蛋白激酶II（CaMK II）的磷酸化以及蛋白激酶A（PKA）的去磷酸化有关。ERK 1/2-CREB通路的抑制降低了记忆相关基因的mRNA水平（fos相关抗原2（fra 2）、CCAAT增强子结合蛋白δ（c/ebpb）、即刻早期基因zif 268（zif 268）、原癌基因c-fos（c-fox）和突触结合蛋白-IV（sytIV））和食欲相关基因的mRNA水平（agouti-related peptide（agrp）andghrelin），PP 1-CREB通路的激活增加了CREB的磷酸化水平，记忆相关基因的mRNA水平，（fra 2、c/ebpb、zif 268和c-fox）和食欲相关基因（pro-opiomelanocortin（pomc）和leptin）的mRNA水平。鲈鱼摄食习性转变过程中的记忆与ERK 1/2-CREB和PP 1-CREB通路有关，这两条通路可调控记忆相关基因和食欲相关基因的转录。
Memory drove a critical process of feeding habit transformation in Chinese perch when they re-trained to eat dead prey fish. To investigate the regulatory mechanism of cAMP-response element-binding protein (CREB) signaling pathway on the memory of Chinese perch during feeding habit transformation, the phosphorylation levels of upstream signal proteins of CREB between the control group (trained once) and the experimental group (trained twice) were measured. The results illustrated that the re-training was correlated to phosphorylation of extracellular regulated protein kinase (ERK1/2) and calcium/calmodulin-dependent protein kinase II (CaMKII), and dephosphorylation of protein kinase A (PKA) of Chinese perch. Inhibition of ERK1/2-CREB pathway decreased the mRNA levels of memory-related genes ((fos-related antigen 2 (fra2), CCAAT enhancer-binding protein delta (c/ebpb), immediate-early gene zif268 (zif268), proto-oncogenes c-fos (c-fox) and synaptotagmin-IV (sytIV)) and mRNA levels of appetite-related genes (agouti-related peptide (agrp) andghrelin), and activation of PP1-CREB pathway increased the phosphorylated levels of CREB, the mRNA levels of memory-related genes (fra2,c/ebpb,zif268, andc-fox), and the mRNA levels of appetite-related genes (pro-opiomelanocortin (pomc) andleptin) in primary brain cells of Chinese perch. The memory in Chinese perch feeding habit transformation was associated with the ERK1/2-CREB and PP1-CREB pathways, which could regulate the transcription of memory-related genes and appetite-related genes.
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DOI：
10.2307/4002523
发表时间：
1992
期刊：
Journal of Range Management
影响因子：
--
作者：
F. Provenza;J. Pfister;C. Cheney
通讯作者：
F. Provenza;J. Pfister;C. Cheney
影响因子：
3.5
作者：
Ferguson, GD;Wang, HB;Storm, DR
通讯作者：
Storm, DR
腹侧海马中的生长素素信号传导通过PI3K-AKT信号传导刺激了喂养的学习和动机方面。
影响因子：
10.6
作者：
Kanoski, Scott E.;Fortin, Samantha M.;Ricks, Katie M.;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
影响因子：
2.7
作者：
Dailey, Megan J.;Moran, Timothy H.;Johnson, Alexander W.
通讯作者：
Johnson, Alexander W.
影响因子：
5.1
作者：
Gregory D. Ferguson;L. Vician;H. Herschman
通讯作者：
Gregory D. Ferguson;L. Vician;H. Herschman