Use of twins as mutual proxy respondents in a case-control study of breast cancer: effect of item nonresponse and misclassification.
Use of twins as mutual proxy respondents in a case-control study of breast cancer: effect of item nonresponse and misclassification.
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在乳腺癌病例对照研究中使用双胞胎作为相互代理受访者：项目无反应和错误分类的影响。
DOI：
10.1093/aje/152.11.1093
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发表时间：
2000
影响因子：
5
通讯作者：
Mack,TM
中科院分区：
文献类型：
--
作者：
Hamilton,AS;Mack,TM
1988年以前诊断的双胞胎乳腺癌病例对照研究被用来描述当使用双胞胎的替代反应时对比值比的影响。通过广告确定北美疾病不一致的配对，并从671对中的两名成员和391对中的一名成员邮寄问卷。来自代理反应的偏差归因于无反应或错误分类。无反应根据暴露变量的类型、所要求的细节深度、被调查者的病例对照状态、合子性和社会亲密度而有所不同。误分类是最小的，通常是无差异的，kappa统计量和类内相关系数表明代理报告和自我报告之间具有高度的可靠性。通过使用双应答者对，开发了一种方法来调整代理回答的两个偏差来源。这些调整导致研究变量（初潮年龄、生殖因素和激素使用）的优势比发生微小变化。在基于所有调查对象的比值比和仅基于双调查对象的比值比之间观察到更大的差异。这些发现表明，对于这一人群中的这些变量，双胞胎是彼此的可靠代理，应该包括单应答者对的结果。
A case-control study of breast cancer in twins diagnosed before 1988 was used to characterize the effects on odds ratios when proxy responses from co-twins are used. North American disease-discordant pairs were ascertained through advertisements, and mailed questionnaires were returned from both members of 671 pairs and from one member of 391 pairs. Biases from the proxy response were attributed to nonresponse or misclassification. Nonresponse varied according to type of exposure variable, depth of detail requested, joint exposure status of the pair, respondent's case-control status, zygosity, and social closeness of the pair. Misclassification was minimal, generally nondifferential, and a high degree of reliability between the proxy and self-report was indicated by the kappa statistic and the intraclass correlation coefficient. By using double-respondent pairs, a method was developed to adjust proxy responses for both sources of bias. These adjustments resulted in minor changes to the odds ratios for the variables studied (age at menarche, reproductive factors, and hormone use). A larger difference was observed between the odds ratios based on all pairs and those based on double-respondent pairs only. These findings demonstrate that, for these variables in this population, twins are reliable proxies for each other and that results from single-respondent pairs should be included.