The development of white adipose tissue. Effect of litter size on the lipoprotein lipase activity of four adipose-tissue depots, serum immunoreactive insulin and tissue cellularity during the first year of life in male and female rats.
The development of white adipose tissue. Effect of litter size on the lipoprotein lipase activity of four adipose-tissue depots, serum immunoreactive insulin and tissue cellularity during the first year of life in male and female rats.
复制标题
白色脂肪组织的发育。
DOI：
10.1042/bj1860805
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
H. M. Jones
中科院分区：
文献类型：
--
作者：
A. Cryer;H. M. Jones
(1.) 每窝饲养 4 只的雄性和雌性大鼠体重增长速度比每窝饲养 16 只的动物更快。这种差异在雄性中比雌性更显着，并且随着年龄的增长，两性的差异都变得不那么明显。 (2.)小窝动物的生殖器周围、肾周围、皮下和肌内白色脂肪组织部位的相对重量表明它们与大窝动物相比相对肥胖。在 4 窝和 16 窝饲养的动物中，发现四个部位之间脂肪组织分布存在与性别相关的差异。 (3.) 尽管在 30 天龄时，所有动物的白色脂肪组织库中的脂肪细胞比大量饲养的动物更多、更大，但此后的变化模式具有部位和性别特异性。在断奶后期间（30-300天），虽然不同地点之间存在明显的细节差异，但雄性细胞大小增加和雌性细胞数量增加的一般模式成为当比较4窝和16窝动物时观察到的仓库大小差异的重要决定因素。 (4.) 脂蛋白脂肪酶活性，以单位/克新鲜重量表示。在断奶后期间（47-300天龄），与十六组饲养的动物相比，四只一组饲养的动物的组织数量没有变化，每个仓库表达的酶活性仅反映了组织重量的差异。 (5.) 四人饲养的雄性每 10(6) 个细胞的脂蛋白脂肪酶活性高于同龄 16 岁饲养的雄性，但雌性没有变化。 (6.)讨论了四窝饲养的动物的持续高胰岛素血症与观察到的酶活性和白色脂肪组织细胞结构的差异。
(1.) Male and female rats reared in litters of four gained body weight more rapidly than animals reared in litters of 16. The differences were more marked in males than females and became less marked in both sexes with advancing age. (2.) The relative weights of the perigenital, perirenal, subcutaneous and intramuscular white-adipose-tissue sites in the animals from small litters indicated their relative obesity compared with animals from large litters. A sex-related difference in the distribution of adipose tissue between the four sites was seen in animals reared in litters of both four and 16. (3.) Although at 30 days of age all the animals had more numerous and larger fat-cells in their white-adipose-tissue depots than animals reared in large litters, the pattern of change thereafter was both site- and sex-specific. During the post-weaning period (30-300 days), although detailed differences were apparent between sites, a general pattern of increased cell size in males and increased cell numbers in females emerged as being the important determinants responsible for the differences in depot sizes seen when animals from litters of four and 16 were compared. (4.) Lipoprotein lipase activities, expressed as units/g fresh wt. of tissue, in the depots of animals reared in groups of four were unaltered compared with those reared in groups of sixteen during the post-weaning period (47-300 days of age), and enzyme activities expressed per depot merely reflected differences in tissue weights. (5.) Lipoprotein lipase activities per 10(6) cells were higher in males reared in fours compared with those reared in sixteens of equivalent age, but were unaltered for females. (6.) The persistent hyperinsulinaemia of animals reared in litters of four is discussed in relation to the observed differences in enzyme activity and white-adipose-tissue cellularity.