The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations
The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations
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DOI：
10.3945/ajcn.2009.28159
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发表时间：
2010-02-01
影响因子：
7.1
通讯作者：
Crowe, Francesca L.
中科院分区：
文献类型：
--
作者：
Bradbury, Kathryn E.;Skeaff, C. Murray;Crowe, Francesca L.
背景：血清脂肪酸生物标志物在营养流行病学中的使用越来越普遍；然而，缺乏科学证据来证实脂肪酸是以分子百分比(这是传统方法)还是绝对浓度来测量更具信息量。目的：为了促进对这一基本概念的理解，我们检查了以分子百分比或浓度表示的血清肉豆蔻酸和亚油酸预测膳食脂肪和血清胆固醇浓度的能力。设计：对新西兰成年人(n=2732)进行了一项基于人群的横断面分析。分析血清胆固醇酯和磷脂中肉豆蔻酸和亚油酸与膳食脂肪或血清胆固醇的关系。结果：两种测量单位预测饱和脂肪、乳脂和多不饱和脂肪的摄入量相似。调整混杂因素后，平均总胆固醇下降0.18mmoL/L，从占血清胆固醇亚油酸分子百分比的最低到最高的五分之一(P=0.027)。相比之下，从血清胆固醇亚油酸浓度的最低到最高的五分之一，平均总胆固醇增加了1.09mmoL/L(P<；0.001)。血清胆固醇肉豆蔻酸盐的分子百分比和浓度与总胆固醇呈正相关(P<；0.001)。血清磷脂脂肪酸的结果相似。结论：血清肉豆蔻酸和亚油酸以分子百分比而不是以浓度来衡量，预测血清总胆固醇的方式区分了饮食饱和脂肪和多不饱和脂肪的不同降胆固醇效果。AM J Clin Nutr 2010；91：398-405。
Background: The use of serum fatty acid biomarkers in nutritional epidemiology is increasingly common; however, there is an absence of scientific evidence to substantiate whether the measurement of fatty acids as molecular percentages (which is the conventional approach) or as absolute concentrations is more informative.Objective: To advance understanding about this fundamental concept, we examined the ability of serum myristic acid and linoleic acid, expressed as molecular percentages or as concentrations, to predict dietary fat and serum cholesterol concentrations.Design: A cross-sectional analysis of a population-based survey of New Zealand adults (n = 2732) was undertaken. The association of myristic and linoleic acids in serum cholesterol ester and phospholipid with dietary fat or serum cholesterol was assessed.Results: Intake of saturated fat, dairy fat, and polyunsaturated fat was predicted similarly with the use of both units of measurement. After adjustment for confounders, mean total cholesterol decreased by 0.18 mmol/L from the lowest to the highest quintile of serum cholesteryl-linoleate as a molecular percentage (P = 0.027). In contrast, mean total cholesterol increased by 1.09 mmol/L from the lowest to the highest quintile of serum cholesteryl-linoleate concentration (P < 0.001). The molecular percentage and concentration of serum cholesteryl-myristate were positively associated with total cholesterol (P < 0.001). Results for serum phospholipid fatty acids were similar.Conclusion: Serum myristic acid and linoleic acid measured as molecular percentages, but not as concentrations, predict serum total cholesterol in a manner that distinguishes between the differential cholesterolemic effects of dietary saturated and polyunsaturated fats. Am J Clin Nutr 2010;91:398-405.