Prognostic impact of chromosomal alteration of 3q27 on nodal B-cell lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 329 consecutive patients
Prognostic impact of chromosomal alteration of 3q27 on nodal B-cell lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 329 consecutive patients
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DOI：
10.1016/j.leukres.2006.11.004
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Miura, Ikuo
中科院分区：
文献类型：
--
作者：
Niitsu, Nozomi;Okamoto, Masataka;Miura, Ikuo
在30%的弥漫性大B细胞淋巴瘤(DLBCL)中发现了涉及BCL6基因的重排。我们评估了携带3q27易位的B细胞淋巴瘤患者的临床特征和预后。59例3q27易位患者中，滤泡性淋巴瘤(FL)占10.9%，DLBCL占23.1%。有趣的是，3q27易位的FL和DLBCL之间没有预后意义。3q27易位FL患者的无进展生存率显著高于18q21易位FL患者。3q27易位的DLBCL患者的PFS率显著高于18q21易位的患者。这些发现表明3q27易位的存在是DLBCL的一个重要预后因素。(C)2006爱思唯尔有限公司。保留所有权利。
Rearrangements involving the BCL6 gene are found in 30% of diffuse large B-cell lymphomas (DLBCLS). We evaluated the clinical characteristics and prognoses of patients with B-cell lymphoma carrying 3q27 translocations. Among the 59 patients having 3q27 translocation, 10.9% had follicular lymphoma (FL) and 23.1% had DLBCL. It is of interest that the prognostic significance was not found between FL and DLBCL with 3q27 translocations. Progression-free survival (PFS) rate was significantly higher in the FL patients with 3q27 translocation than in those with 18q21 translocation. PFS rate was significantly higher in the DLBCL patients with 3q27 translocation than in those with 18q21 translocation. These findings suggest that the presence of 3q27 translocation is a significant prognostic factor in DLBCL. (c) 2006 Elsevier Ltd. All rights reserved.