Investigating Brain Network Changes and Their Association With Cognitive Recovery After Traumatic Brain Injury: A Longitudinal Analysis
Investigating Brain Network Changes and Their Association With Cognitive Recovery After Traumatic Brain Injury: A Longitudinal Analysis
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DOI：
10.3389/fneur.2020.00369
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发表时间：
2020-06-09
影响因子：
3.4
通讯作者：
Taylor, Peter Neal
中科院分区：
文献类型：
--
作者：
Moreira da Silva, Nadia;Cowie, Christopher J. A.;Taylor, Peter Neal
创伤性脑损伤（TBI）可导致急性认知功能障碍和弥漫性轴索损伤，表现为白色脑网络改变，这些改变可能会或可能不会在以后恢复。我们的目标是首先描述TBI后大脑网络变化的方式，其次，调查这些变化是否与认知缺陷的恢复有关。我们的目标是在辨别大脑网络变化之间的关系方面取得初步进展，以及它们（dys）的功能相关性。我们分析了23例TBI患者（两个时间点：伤后6天，12个月）的纵向MRI和28例对照组的横断面数据，以构建白色脑网络。还进行了认知评估。应用图论和回归分析来识别损伤后与随后认知功能改善相关的脑网络指标的变化。16个脑网络指标被发现是不同的损伤后阶段的歧视。其中11个解释了90%（调整R（2））的TBI后认知恢复的变异性。除了前扣带皮层外，在额叶和颞叶皮层中发现了对解释方差有很大贡献的脑网络指标。我们的初步研究表明，网络重组可能与TBI后第一年受损认知功能的恢复有关。
Traumatic brain injury (TBI) can result in acute cognitive deficits and diffuse axonal injury reflected in white matter brain network alterations, which may, or may not, later recover. Our objective is to first characterize the ways in which brain networks change after TBI and, second, investigate if those changes are associated with recovery of cognitive deficits. We aim to make initial progress in discerning the relationships between brain network changes, and their (dys)functional correlates. We analyze longitudinally acquired MRI from 23 TBI patients (two time points: 6 days, 12 months post-injury) and cross-sectional data from 28 controls to construct white matter brain networks. Cognitive assessment was also performed. Graph theory and regression analysis were applied to identify changed brain network metrics after injury that are associated with subsequent improvements in cognitive function. Sixteen brain network metrics were found to be discriminative of different post-injury phases. Eleven of those explain 90% (adjustedR(2)) of the variability observed in cognitive recovery following TBI. Brain network metrics that had a high contribution to the explained variance were found in frontal and temporal cortex, additional to the anterior cingulate cortex. Our preliminary study suggests that network reorganization may be related to recovery of impaired cognitive function in the first year after a TBI.