Amanita poisoning: a clinical-histopathological study of 64 cases of intoxication.
Amanita poisoning: a clinical-histopathological study of 64 cases of intoxication.
复制标题
鹅膏中毒：64 例中毒病例的临床组织病理学研究。
作者：
F. B. S. Omer;A. Giannini;P. Botti;L. Caramelli;Fabrizio Ledda;S. Peruzzi;M. Zorn
在过去的几年里，新的和有效的治疗方案已被用于治疗病人中毒的毒伞属蘑菇。因此，生存率大大提高，临床-组织病理学相关性研究，如本研究，已成为可能。这些病人的命运曾经被错误地认为要么完全康复（很少），要么死亡（经常）。根据目前的研究结果，金刚伞中毒也可发展为慢性肝损害。这种疾病的后一种演变似乎取决于中毒急性期的严重程度，肝改变的临床、实验室和活检结果证明了这一点。对发展中的肝损害的正确评估包括组织病理学检查，这应该在急性发作6个月后，在克服中度至重度急性中毒的患者中进行。
In the last few years new and effective therapeutic schedules have been employed in the treatment of patients intoxicated by mushrooms of the genus Amanita. As a result, the survival rate has considerably increased and clinical-histopathological correlation studies, such as the present one, have become feasible. The fate of these patients was once wrongly considered to be either complete recovery (rarely) or death (frequently). According to the results of the present study, Amanita intoxication can also progress to chronic liver damage. This latter evolution of the disease seems to depend on the severity of the acute phase of the intoxication, as clinical, laboratory and biopsy findings of liver alteration testify. The correct evaluation of evolving liver damage involves histopathological investigations, which should be performed 6 months after the acute episode, in those patients who overcome a moderate to severe acute intoxication.