Where splicing joins chromatin
Where splicing joins chromatin
复制标题
DOI：
10.4161/nucl.2.3.15876
复制
发表时间：
2011-05-01
期刊：
影响因子：
3.7
通讯作者：
Stanek, David
中科院分区：
文献类型：
--
作者：
Hnilicova, Jarmila;Stanek, David
大量数据表明，基因表达的两个关键步骤-转录和剪接相互影响。很长一段时间以来，人们都知道染色质修饰调节转录，但最近才发现染色质和组蛋白修饰在前体mRNA剪接中起着重要作用。在这里，我们总结剪接机制和染色质之间的相互作用，并讨论其潜在的功能意义。我们主要集中在组蛋白乙酰化和甲基化及其在剪接中的作用的潜在机制。似乎组蛋白乙酰化主要通过改变转录速率起作用，而组蛋白甲基化也可以通过招募各种剪接组分直接影响剪接。
There are numerous data suggesting that two key steps in gene expression-transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components.