Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome
Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome
复制标题
DOI：
10.1136/ard.2003.019794
复制
发表时间：
2005-01-01
影响因子：
27.4
通讯作者：
Mariette, X
中科院分区：
文献类型：
--
作者：
Gottenberg, JE;Mignot, S;Mariette, X
目的：调查的患病率抗环瓜氨酸肽（抗CCP）和抗角蛋白抗体（AKA）在原发性Sjogren综合征的患者。方法：149例原发性Sjogren综合征的诊断根据欧洲/美国的共识标准，从三个法国医疗中心招募。酶联免疫吸附试验测定抗CCP抗体的存在，间接免疫荧光法测定AKA抗体的存在。手和脚的X光片进行了评价时的抗CCP analysis.Results：6例放射性糜烂和9例非糜烂性关节炎符合ACR标准的类风湿关节炎被认为有类风湿关节炎和继发性干燥综合征，而134被认为有原发性干燥综合征（平均（SD）的疾病持续时间，11.1（6.6）年）。其中，80例IgM类风湿因子（RF）检测阳性（59%），10例抗CCP阳性（7.5%），7例AKA阳性（5.2%），5例抗CCP和AKA均阳性（3.7%）。抗CCP抗体阳性和阴性患者的临床和生物学特征，包括RF的患病率没有差异。9名非糜烂性关节炎的干燥综合征患者，符合类风湿关节炎的ACR标准，均为CCP阳性。他们的疾病修饰抗风湿药物的反应可能是不同的经典类风湿patients.Conclusions：大多数原发性干燥综合征患者是阴性的AKA和抗CCP，但阳性的测试结果不应排除这种诊断。抗CCP抗体阳性的患者，谁可能容易发展为类风湿关节炎，需要谨慎的临床和放射学随访。
Objective: To investigate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin antibodies (AKA) in patients with primary Sjogren's syndrome.Methods: 149 patients with a diagnosis of primary Sjogren's syndrome according to the European/American consensus criteria were recruited from three French medical centres. The presence of anti-CCP was determined by enzyme linked immunosorbent assay and of AKA antibodies by indirect immunofluorescence. Radiographs of hands and feet were evaluated at the time of anti-CCP analysis.Results: Six patients with radiological erosions and nine patients with non-erosive arthritis fulfilling ACR criteria for rheumatoid arthritis were thought to have rheumatoid arthritis and secondary Sjogren's syndrome, while 134 were considered to have primary Sjogren's syndrome (mean (SD) disease duration, 11.1 (6.6) years). Of these, 80 tested positive for IgM rheumatoid factor (RF) (59%), 10 (7.5%) for anti-CCP, 7 (5.2%) for AKA, and 5 (3.7%) for both anti-CCP and AKA. There was no difference in clinical and biological features, including prevalence of RF, between anti-CCP positive and negative patients. The nine Sjogren patients with non-erosive arthritis, fulfilling ACR criteria for rheumatoid arthritis, were all CCP positive. Their response to disease modifying antirheumatic drugs could be different from classical rheumatoid patients.Conclusions: Most patients with primary Sjogren's syndrome are negative for AKA and anti-CCP, but positive test results should not rule out this diagnosis. Anti-CCP positive patients, who may be prone to developing rheumatoid arthritis, require cautious clinical and radiographic follow up.