Paradigm 'flipping' to reinvigorate translational science: Outlining a neurodevelopmental science framework from a 'neurodiversity' perspective
Paradigm 'flipping' to reinvigorate translational science: Outlining a neurodevelopmental science framework from a 'neurodiversity' perspective
复制标题
范式“翻转”重振转化科学：从“神经多样性”角度概述神经发育科学框架
DOI：
10.1111/jcpp.13886
复制
发表时间：
2023
影响因子：
7.6
通讯作者：
Sonuga-Barke E
中科院分区：
文献类型：
--
作者：
Sonuga-Barke E
在大多数情况下，神经发育状况的科学，如自闭症和ADHD，是在一个由范式定义的框架内进行的，该范式假设这些神经发育变异的表达是由大脑功能障碍引起的障碍。翻译的目标是识别，然后瞄准，这种功能障碍的来源，以减少障碍和解决障碍。通过将这种观点转变为一种将这种情况定义为以大脑相似性为基础的思想和行动的分歧的观点，神经多样性范式提供了一种新的翻译命令所塑造的新的科学视野。它将研究的重点转移到理解环境塑造经验的方式，以扼杀或促进神经分歧者的福祉和发展。它还鼓励神经分歧者尽可能充分地参与科学过程。这两个要素共同为神经发育的新转化科学提供了一个平台。
For the most part the science of neuro‐developmental conditions, such as autism and ADHD, is conducted within a framework defined by a paradigm thatassumes that these expressions of neuro‐developmental variation are disorders resulting from brain dysfunction.the translational goal being to identify, then target, the source of such dysfunction to reduce disorder and resolve impairment. By shifting this perspective to one that defines such conditions asdivergence in thought and action underpinned by brain atypicality, the neurodiversity paradigm offers a fresh scientific vision shaped by a new translational imperative. It shifts the focus of enquiry to understanding the way environments shape experience to either stifle or promote the well‐being and development of neurodivergent people. It also encourages the fullest possible participation of neurodivergent people in the scientific process. Together these two elements provide a platform for a new translational science of neurodevelopment.