Novelty responses to relational and non-relational information in the hippocampus and the parahippocampal region:: A comparison based on event-related fMRI
Novelty responses to relational and non-relational information in the hippocampus and the parahippocampal region:: A comparison based on event-related fMRI
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DOI：
10.1002/hipo.20098
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Menon, RS
中科院分区：
文献类型：
--
作者：
Köhler, S;Danckert, S;Menon, RS
我们进行了两项功能磁共振成像（fMRI）实验，检查人类内侧颞叶（MTL）的新奇反应，以确定海马体对记忆处理的贡献是否与邻近海马旁区域的结构不同。鉴于这种差异贡献可能与关系处理需求有关，我们评估了 MTL 中新的单一对象以及新的空间和非空间对象关系的事件相关 fMRI 响应；受试者被要求在之前研究的物品中检测这些不同类型的新奇事物，他们在扫描过程中成功地完成了这项任务。海马和嗅周皮层区域反应模式中出现的双重解离为 MTL 的功能专业化提供了最有力的支持。右海马体中部的一个区域对空间和非空间关系的新颖性有反应，但对单个物体的新颖性没有反应。相比之下，位于前副沟的右侧鼻周皮层区域对单个物体的新颖性做出了反应，但对任何一种关系都没有反应。在本研究中对新颖性做出反应的其他 MTL 区域在对各种新颖性类型的反应上没有显示出可靠的差异；这些区域包括海马体的前部和海马旁皮质的后部。总之，我们的研究结果表明，关系处理需求是人类 MTL 功能专业化的关键决定因素。然而，他们还表明，仅区分海马和海马旁区域的神经解剖学框架不足以解释在人类 MTL 中的关系过程中观察到的所有功能差异和相似之处。 (c) 2005 年 Wiley-Liss, Inc.
We conducted two functional magnetic resonance imaging (fMRI) experiments that examined novelty responses in the human medial temporal lobe (MTL) to determine whether the hippocampus makes contributions to memory processing that differ from those of structures in the adjacent parahippocampal region. In light of proposals that such differential contributions may pertain to relational processing demands, we assessed event-related fMRI responses in the MTL for novel single objects and for novel spatial and non-spatial object relationships; subjects were asked to detect these different types of novelties among previously studied items, and they successfully performed this task during scanning. A double dissociation that emerged from the response pattern of regions in the hippocampus and perirhinal cortex provided the strongest support for functional specialization in the MTL. A region in the right middle hippocampus responded to the novelty of spatial and non-spatial relationships but not to the novelty of individual objects. By contrast, a region in right perirhinal cortex, situated in the anterior collateral sulcus, responded to the novelty of individual objects but not to that of either type of relationship. Other MTL regions that responded to novelty in the present study showed no reliable difference in their response to the various novelty types; these regions included anterior parts of the hippocampus and posterior aspects of parahippocampal cortex. Together, our findings indicate that relational processing demands are a critical determinant of functional specialization in the human MTL. They also suggest, however, that a neuroanatomical framework that only distinguishes between the hippocampus and the parahippocampal region is not sufficiently refined to account for all functional differences and similarities observed with respect to relational processes in the human MTL. (c) 2005 Wiley-Liss, Inc.