Spinal cord atrophy in multiple sclerosis caused by white matter volume loss
Spinal cord atrophy in multiple sclerosis caused by white matter volume loss
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DOI：
10.1001/archneur.62.12.1859
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发表时间：
2005-12-01
影响因子：
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通讯作者：
Evangelou, N
中科院分区：
文献类型：
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作者：
Gilmore, CP;DeLuca, GC;Evangelou, N
目的：评估多发性硬化（MS）患者脊髓萎缩中白色物质（WM）和灰质（GM）体积损失的相对贡献。设计：对5个节段脊髓的横切面进行尸检研究，测量GM和WM的横切面面积。设置：英国诺丁汉诺丁汉大学神经病理学系。患者：55例MS病例和33例对照。主要结果测量：WM和GM区域的大小。结果：WM区域在MS病例中在上脊髓水平而不是下脊髓水平显著减少。结论：MS的脊髓萎缩是由于WM，而不是GM体积的损失。
Objective: To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS).Design: Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas.Setting: Department of Neuropathology, University of Nottingham, Nottingham, England. Patients: Fifty-five MS cases and 33 controls.Main Outcome Measures: Size of the WM and GM areas.Results: The WM area was significantly reduced in MS cases in the upper but not the lower cord levels. The GM area was not significantly different between MS and control cases.Conclusion: Spinal cord atrophy in MS is due to WM rather than GM volume loss.