The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
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DOI：
10.1111/j.1460-9568.2010.07550.x
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Bohbot, Veronique D.
中科院分区：
文献类型：
--
作者：
Banner, Harrison;Bhat, Venkataramana;Bohbot, Veronique D.
在导航过程中，多个记忆系统参与空间信息的并行处理。一系列的研究已经区分了依赖于校园的“空间”导航和基于习惯的“反应”学习，前者依赖于对环境中地标之间关系的了解来构建认知地图，后者需要记住一系列动作，并由尾状核介导。研究表明，人们自发地使用这两种替代导航策略中的一种来解决给定的导航任务，其频率几乎相等，并且该策略与功能性磁共振成像（fMRI）活动和灰质密度相关。虽然有证据表明经验调节海马体中的灰质，但遗传贡献也可能在海马体和尾状核中发挥重要作用。最近，脑源性神经营养因子（BDNF）基因的Val66Met多态性已成为海马功能的可能抑制剂。我们研究了脑源性神经营养因子Val66Met多态性在功能磁共振成像导航任务中对虚拟导航行为和大脑激活的作用。我们的研究结果表明，自发的策略，其中'Met'载体使用的响应策略更频繁地比个人的'瓦尔'等位基因纯合子的遗传贡献。此外，我们发现增加海马激活的瓦尔组相对于Met组在虚拟导航任务的性能。我们的研究结果支持的想法，BDNF基因与Val66Met多态性是一种新的候选基因参与决定自发的策略，在导航行为。
Multiple memory systems are involved in parallel processing of spatial information during navigation. A series of studies have distinguished between hippocampus-dependent 'spatial' navigation, which relies on knowledge of the relationship between landmarks in one's environment to build a cognitive map, and habit-based 'response' learning, which requires the memorization of a series of actions and is mediated by the caudate nucleus. Studies have demonstrated that people spontaneously use one of these two alternative navigational strategies with almost equal frequency to solve a given navigation task, and that strategy correlates with functional magnetic resonance imaging (fMRI) activity and grey matter density. Although there is evidence for experience modulating grey matter in the hippocampus, genetic contributions may also play an important role in the hippocampus and caudate nucleus. Recently, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene has emerged as a possible inhibitor of hippocampal function. We have investigated the role of the BDNF Val66Met polymorphism on virtual navigation behaviour and brain activation during an fMRI navigation task. Our results demonstrate a genetic contribution to spontaneous strategies, where 'Met' carriers use a response strategy more frequently than individuals homozygous for the 'Val' allele. Additionally, we found increased hippocampal activation in the Val group relative to the Met group during performance of a virtual navigation task. Our results support the idea that the BDNF gene with the Val66Met polymorphism is a novel candidate gene involved in determining spontaneous strategies during navigation behaviour.