Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications
Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications
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DOI：
10.1016/j.micpath.2021.105288
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发表时间：
2021-11-17
影响因子：
3.8
通讯作者：
Mahmood, Saffari
中科院分区：
文献类型：
--
作者：
Foroogh, Neamati;Rezvan, Moniri;Mahmood, Saffari
1型菌毛负责细菌的致病性和生物被膜的产生，这是泌尿系致病大肠杆菌菌株的重要毒力因素。FIMH上发表了许多文章，但每一篇都研究了这种蛋白质的一个特定方面。目前的综述研究旨在集中在结构和构象的变化，并描述了在尿路感染的新的潜在治疗方法、分型方法和表达系统中使用该蛋白的努力。目前的研究是第一次简要而有效地研究与FIMH粘附素相关的问题的综述。
Type 1 fimbriae are responsible for bacterial pathogenicity and biofilm production, which are important virulence factors in uropathogenic Escherichia coli strains. Many articles are published on fimH, but each examined a specific aspect of this protein. The current review study aimed at focusing on structure and conformational changes and describing efforts to use this protein in novel potential treatments for urinary tract infections, typing methods, and expression systems. The current study was the first review that briefly and effectively examined issues related to fimH adhesin.