Current Neural and Behavioral Dimensional Constructs across Mood Disorders.
Current Neural and Behavioral Dimensional Constructs across Mood Disorders.
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DOI：
10.1007/s40473-014-0018-x
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发表时间：
2014-09-01
影响因子：
1.7
通讯作者：
Passarotti AM
中科院分区：
文献类型：
--
作者：
Langenecker SA;Jacobs RH;Passarotti AM
我们对情绪障碍的潜在神经生物学的理解仍然有限。我们提出了一个概念化和理解情绪障碍的综合模型，借鉴了与情绪障碍相关的广泛文献。情绪加工和调节的整合模型结合了研究领域标准（RDoC）倡议的语言结构。我们特别关注正效域/回路（PVC），重点介绍了最近的奖励研究和负效域/回路（NVC），重点介绍了反刍。此外，我们还举例说明了认知控制和问题解决（CCaPS）电路，它大量参与情绪调节，以及默认模式网络（DMN）和电路之间的相互作用。最后，我们提出了解决情绪障碍发展研究中的挑战的方法，包括使用包含许多障碍风险的高风险设计。
Our understanding of the underlying neurobiology for mood disorders is still limited. We present an integrated model for conceptualizing and understanding mood disorders drawing upon a broad literature pertinent to mood disorders. The integrated model of emotion processing and regulation incorporates the linguistic constructs of the Research Domain Criteria (RDoC) initiative. In particular, we focus on the Positive Valence domain/circuit (PVC), highlighting recent reward research and the Negative Valence domain/circuit (NVC), highlighting rumination. Furthermore, we also illustrate the Cognitive Control and Problem Solving (CCaPS) circuit, which is heavily involved in emotion regulation, as well as the default mode network (DMN) and interactions between circuits. We conclude by proposing methods for addressing challenges in the developmental study of mood disorders including using high-risk design that incorporates risk for many disorders.