PRESAGE: PRivacy-preserving gEnetic testing via SoftwAre Guard Extension.

PRESAGE: PRivacy-preserving gEnetic testing via SoftwAre Guard Extension.
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DOI:
10.1186/s12920-017-0281-2
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发表时间:
2017-07-26
影响因子:
2.7
通讯作者:
Wang S
Wang S
中科院分区:
医学3区
文献类型:
--
作者:
Chen F;Wang C;Dai W;Jiang X;Mohammed N;Al Aziz MM;Sadat MN;Sahinalp C;Lauter K;Wang S

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DNA 测序技术的进步促进了基因组的广泛应用,以改善医疗保健并促进生物医学研究。然而,隐私和安全问题已成为利用云计算处理敏感基因组数据的挑战。我们提出了基于软件防护扩展 (SGX) 的安全外包基因测试框架的首批实现之一,该框架利用多种加密协议和最小完美哈希方案来实现高效、安全的数据存储和计算外包。我们将所提出的 PRESAGE 框架的性能与最先进的同态加密方案以及明文实现进行了比较。实验结果表明,同态加密方法具有显着的性能,并且与明文实现相比,计算开销较小。拟议的 PRESAGE 通过使用结合了安全硬件和多个加密协议的混合框架,为不受信任的云中安全高效的基因组数据外包提供了一种替代解决方案。
Advances in DNA sequencing technologies have prompted a wide range of genomic applications to improve healthcare and facilitate biomedical research. However, privacy and security concerns have emerged as a challenge for utilizing cloud computing to handle sensitive genomic data. We present one of the first implementations of Software Guard Extension (SGX) based securely outsourced genetic testing framework, which leverages multiple cryptographic protocols and minimal perfect hash scheme to enable efficient and secure data storage and computation outsourcing. We compared the performance of the proposed PRESAGE framework with the state-of-the-art homomorphic encryption scheme, as well as the plaintext implementation. The experimental results demonstrated significant performance over the homomorphic encryption methods and a small computational overhead in comparison to plaintext implementation. The proposed PRESAGE provides an alternative solution for secure and efficient genomic data outsourcing in an untrusted cloud by using a hybrid framework that combines secure hardware and multiple crypto protocols.
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