Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: A twin study
Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: A twin study
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DOI：
10.1016/j.schres.2006.08.009
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发表时间：
2007-01-01
影响因子：
4.5
通讯作者：
Boutros, Nashaat N.
中科院分区：
文献类型：
--
作者：
Anokhin, Andrey P.;Vedeniapin, Andrei B.;Boutros, Nashaat N.
通过P50听觉事件相关电位（ERP）抑制测量的感觉门控缺陷与精神分裂症和其他一些精神疾病的生物学基础有关，并被提议作为遗传学研究的候选内表型。最近的研究表明，精神分裂症患者的门控缺陷延伸到反映早期注意处理的ERP成分（N1/P2复合体）。然而，在一般人群中的感觉门控的遗传性的证据是非常有限的。在54对同卵双生子和55对异卵双生子中，使用双击听觉范式估计P50、N1和P2振幅和门控的遗传度。遗传模型拟合分析表明，P50，N1和P2波的峰值振幅的遗传力高。P50门控（S2/S1）的遗传影响不大，而NI和P2门控的遗传力很高且显著。替代门控措施（S1-S2差异）显示所有三个ERP组件的显着遗传力。P50门控比的弱遗传影响可能与其在先前研究中表现出的差的重测信度有关。这些结果表明，来自N1/P2波复合体的门控措施可能是有用的内表型为基础的遗传研究的感觉门控功能及其损害的精神病理学。(c)2006 Elsevier B. V.保留所有权利。
A deficit in sensory gating measured by the suppression of P50 auditory event-related potential (ERP) has been implicated in the biological bases of schizophrenia and some other psychiatric disorders and proposed as a candidate endophenotype for genetic studies. More recently, it has been shown that gating deficits in schizophrenics extend to ERP components reflecting early attentive processing (the N1/P2 complex). However, evidence for heritability of sensory gating in the general population is very limited. Heritability of P50, N1, and P2 amplitudes and gating was estimated in 54 monozygotic and 55 dizygotic twin pairs using a dual-click auditory paradigm. Genetic model-fitting analysis showed high heritability of peak amplitudes of P50, N1, and P2 waves. Genetic influences on P50 gating (S2/S1) were modest, while heritability of NI and P2 gating was high and significant. The alternative gating measure (S1-S2 difference) showed significant heritability for all three ERP components. Weak genetic influences on P50 gating ratio can be related to its poor test-retest reliability demonstrated in previous studies. These results suggest that gating measures derived from the N1/P2 wave complex may be useful endophenotypes for population-based genetic studies of the sensory gating function and its impairments in psychopathology. (c) 2006 Elsevier B.V. All rights reserved.