Stress reactivity in young marmosets (Callithrix geoffroyi): Ontogeny, stability, and lack of concordance among co-twins
Stress reactivity in young marmosets (Callithrix geoffroyi): Ontogeny, stability, and lack of concordance among co-twins
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DOI：
10.1016/j.yhbeh.2011.12.006
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发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
Korgan, Austin
中科院分区：
文献类型：
--
作者：
French, Jeffrey A.;Smith, Adam S.;Korgan, Austin
已知下丘脑-垂体-肾上腺（HPA）轴反应方式的变化是短期和长期健康结果的预测因子。HPA对压力源的反应的性质随着发育阶段而变化，并且压力反应的某些组分表现出长期的个体一致性（即，是特质样的）而其他是瞬时的或可变的（即，类国家）。在这里，我们评估了绒猴（Callithrix geoffroyi）在三个不同的发展阶段：青少年，亚成年和年轻的成年人的标准化社会应激源（社会分离和暴露于一个新的环境）的反应。我们监测了尿皮质醇（CORT）水平，并得出了HPA活性的多项指标：基线CORT、CORT反应性、CORT曲线下面积（AUC）和CORT调节。幼年的绒猴表现出最剧烈的应激反应，具有较高的AUC，并且倾向于表现出较差的调节。虽然基线CORT和CORT调节在不同年龄的个体内不一致，但CORT反应性和AUC测量值在不同时间高度相关：即，具有高应激反应性和AUC的个体作为青少年也具有高测量值作为亚成体和成体，反之亦然。绒猴双胞胎没有表现出类似的应激反应模式。这些数据表明，无论在绒猴的压力反应风格的变化来源，个别独特的模式建立了6个月的年龄，并持续至少一年的整个绒猴生活史的不同阶段。(C)2011 Elsevier Inc. All rights reserved.
Variation in response styles in the hypothalamic-pituitary-adrenal (HPA) axis are known to be predictors of short- and long-term health outcomes. The nature of HPA responses to stressors changes with developmental stage, and some components of the stress response exhibit long-term individual consistency (i.e., are trait-like) while others are transient or variable (i.e., state-like). Here we evaluated the response of marmoset monkeys (Callithrix geoffroyi) to a standardized social stressor (social separation and exposure to a novel environment) at three different stages of development: juvenile, subadult, and young adult. We monitored levels of urinary cortisol (CORT), and derived multiple measures of HPA activity: Baseline CORT, CORT reactivity, CORT Area Under the Curve (AUC), and CORT regulation. juvenile marmosets exhibited the most dramatic stress response, had higher AUCs, and tended to show poorer regulation. While baseline CORT and CORT regulation were not consistent within an individual across age, CORT reactivity and measures of AUC were highly correlated across time: i.e., individuals with high stress reactivity and AUC as juveniles also had high measures as subadults and adults, and vice-versa. Marmoset co-twins did not exhibit similar patterns of stress reactivity. These data suggest that regardless of the source of variation in stress response styles in marmosets, individually-distinctive patterns are established by six months of age, and persist for at least a year throughout different phases of marmoset life history. (C) 2011 Elsevier Inc. All rights reserved.