Assessment of left ventricular deformation in patients with type 2 diabetes mellitus by cardiac magnetic resonance tissue tracking
Assessment of left ventricular deformation in patients with type 2 diabetes mellitus by cardiac magnetic resonance tissue tracking
复制标题
心脏磁共振组织追踪评估2型糖尿病患者左心室变形
DOI：
10.1038/s41598-020-69977-x
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发表时间：
2020-08-04
影响因子：
4.6
通讯作者：
Guo, Ying-kun
中科院分区：
文献类型：
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作者：
Xie, Lin-jun;Dong, Zhi-hui;Guo, Ying-kun
采用心脏磁共振（CMR）组织追踪技术量化2型糖尿病（T2 DM）患者左心室（LV）整体和局部心肌应变，并确定心肌应变参数评估LV变形的能力。我们的研究包括98例成人T2 DM患者（左室射血分数[LVEF]保留，72例; LVEF降低，26例）和35例健康对照。常规左室功能、容积-时间曲线参数及左室重构指数均采用CMR测量。使用CMR组织追踪测量整体和局部LV心肌应变参数，并在不同亚组之间进行比较。应用受试者工作特征分析评价诊断准确性。进行回归分析，以确定应变参数和LV重构指数之间的关系。结果显示，左室射血分数降低组与对照组的径向峰值应变（PS）和周向PS无显著性差异（P> 0.05）。然而，左室射血分数下降组的纵向PS显著低于对照组（P= 0.005）。多因素线性回归分析和Logistic回归分析显示，左室重构指数与总体纵向PS独立相关（β = 0.385，P < 0.001）。总之，在T2 DM患者中，使用CMR组织跟踪可以成功地对心脏变形进行早期定量评价。此外，整体纵向PS可以补充LVEF评估心功能。
To quantify the global and regional left ventricular (LV) myocardial strain in type 2 diabetes mellitus (T2DM) patients using cardiac magnetic resonance (CMR) tissue-tracking techniques and to determine the ability of myocardial strain parameters to assessment the LV deformation. Our study included 98 adult T2DM patients (preserved LV ejection fraction [LVEF], 72; reduced LVEF, 26) and 35 healthy controls. Conventional LV function, volume-time curve parameters and LV remodeling index were measured using CMR. Global and regional LV myocardial strain parameters were measured using CMR tissue tracking and compared between the different sub-groups. Receiver operating characteristic analysis was used to assess the diagnostic accuracy. Regression analyses were conducted to determine the relationship between strain parameters and the LV remodeling index. The results show that global radial peak strain (PS) and circumferential PS were not significantly different between the preserved-LVEF group and control group (P> 0.05). However, longitudinal PS was significantly lower in the preserved-LVEF group than in the control group (P= 0.005). Multivariate linear and logistic regression analyses showed that global longitudinal PS was independently associated (β = 0.385,P< 0.001) with the LV remodeling index. In conclusion, early quantitative evaluation of cardiac deformation can be successfully performed using CMR tissue tracking in T2DM patients. In addition, global longitudinal PS can complement LVEF in the assessment of cardiac function.