ACTIVATION OF UNMYELINATED AFFERENTS IN CHRONICALLY LESIONED NERVES BY ADRENALINE AND EXCITATION OF SYMPATHETIC EFFERENTS IN THE CAT
ACTIVATION OF UNMYELINATED AFFERENTS IN CHRONICALLY LESIONED NERVES BY ADRENALINE AND EXCITATION OF SYMPATHETIC EFFERENTS IN THE CAT
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DOI：
10.1016/0304-3940(87)90167-4
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发表时间：
1987-11-10
影响因子：
2.5
通讯作者：
KOLTZENBURG, M
中科院分区：
文献类型：
--
作者：
HABLER, HJ;JANIG, W;KOLTZENBURG, M
在猫实验中，通过将切断的后肢皮神经的近端残端缝合到切断的胫神经的远端残端来制作连续性神经瘤。11~20个月后，通过电记录从神经瘤近端的神经细丝中识别出单一的无髓纤维。当对腰交感神经干(LST)或静脉注射进行重复电刺激时。注射肾上腺素、C纤维的30根纤维中有14根可被至少一种刺激所兴奋(其中12根由肾上腺素兴奋，7根由LST刺激引起)。对LST刺激有反应的纤维已经被低频刺激(1-2赫兹)充分兴奋。在已知导致反射的全身性低氧期间，在6个C纤维中有4个诱发了传出交感神经活动反应。因此，模拟交感神经活动的生理条件的刺激可以兴奋慢性受损神经中的传入C纤维。
Neuroma-in-continuity was experimentally produced in cats by suturing the proximal stump of a transected hindlimb cutaneous nerve to the distal stump of the transected tibial nerve. Eleven to 20 months afterwards single non-myelinated fibres were identified by electrical recording from filaments of the nerves proximally from the neuroma. When tested with repetitive electrical stimulation of the lumbar sympathetic trunk (LST) or i.v. injections of adrenaline, C-fibres in 14 out of 30 filaments were excited by at least one of these stimuli (12 by adrenalin, 7 by stimulation of LST). The fibres responding to LST stimulation were already substantially excited by low frequency stimulation (1–2 Hz). During systemic hypoxia known to result in reflex increases of efferent sympathetic activity responses were elicited in 4 out of 6 C-fibres. Thus, stimuli simulating physiological conditions of sympathetic activity can excite afferent C-fibres in a chronically lesioned nerve.