Clinical Course of Patients With Hyponatremia and Decompensated Systolic Heart Failure and the Effect of Vasopressin Receptor Antagonism With Tolvaptan
Clinical Course of Patients With Hyponatremia and Decompensated Systolic Heart Failure and the Effect of Vasopressin Receptor Antagonism With Tolvaptan
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DOI：
10.1016/j.cardfail.2013.04.001
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发表时间：
2013-06-01
影响因子：
6
通讯作者：
Udelson, James E.
中科院分区：
文献类型：
--
作者：
Hauptman, Paul J.;Burnett, John;Udelson, James E.
背景：失代偿性心力衰竭、容量超负荷和低钠血症患者的处理具有挑战性。关于这些患者在标准住院治疗期间的临床病程或使用加压素拮抗剂的文献相对较少。方法和结果：利用托伐普坦数据库对加压素拮抗剂在心力衰竭预后研究中的有效性进行评估，以评估心力衰竭并低钠血症住院患者的短期临床病程以及托伐普坦对预后的影响。在安慰剂组中，低钠血症患者(血清Na+
Background: Patients with decompensated heart failure, volume overload, and hyponatremia are challenging to manage. Relatively little has been documented regarding the clinical course of these patients during standard in-hospital management or with vasopressin antagonism.Methods and Results: The Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan database was examined to assess the short-term clinical course of patients hospitalized with heart failure and hyponatremia and the effect of tolvaptan on outcomes. In the placebo group, patients with hyponatremia (serum Na+