Dissolved urate salts out calcium oxalate in undiluted human urine in vitro: Implications for calcium oxalate stone genesis
Dissolved urate salts out calcium oxalate in undiluted human urine in vitro: Implications for calcium oxalate stone genesis
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DOI：
10.1016/s1074-5521(03)00057-7
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发表时间：
2003-03-01
影响因子：
--
通讯作者：
Ryall, RL
中科院分区：
文献类型：
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作者：
Grover, PK;Marshall, VR;Ryall, RL
长期以来，高尿酸尿症一直被认为是草酸钙结石发病的易感因素。然而，其作用机制尚无可靠的科学依据。此前，我们通过添加溶解的尿酸钠模拟了高尿酸尿症，促进了CaOx的结晶。在目前的研究中，我们证明了尿酸盐对结晶的影响是由于它从溶液中盐析出CaOx。此外，对尿液的分析表明，它们的亚稳极限随着钙和尿酸盐浓度乘积的增加而降低：这对CaOx结石的成因有一定的意义。我们还概述了未来预防和/或治疗CaOx结石的研究的抗盐策略。
Hyperuricosuria has long been documented as a predisposing factor to calcium oxalate (CaOx) stone pathogenesis. However, its mechanism is still without sound scientific foundation. Previously, we showed that hyperuricosuria, simulated by the addition of dissolved sodium urate, promotes the crystallization of CaOx. In the present study, we demonstrate that the urate's effect on the crystallization is attributable to its salting out CaOx from solution. Furthermore, analysis of urines revealed that their metastable limit decreased with increases in the product of the prevailing concentrations of calcium and urate: this has implications for CaOx stone genesis. We also outline antisalting out strategies for future research for the prevention and/or treatment of CaOx calculi.